Innovation in CRC Research: Targeting SPACA6P-AS for Progression.

Autor: Ma T; Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China., Jin Y; Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China., Wang S; Department of Colorectal Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Hu H; Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China., Wang M; Department of Colorectal Surgery, Zhejiang Cancer Hospital (Affiliated Cancer Hospital of the Chinese Academy of Sciences), Hangzhou, China., Yan G; Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China., Tang Q; Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China., Huang R; Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China., Wang G; Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jazyk: angličtina
Zdroj: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Dec; Vol. 38 (12), pp. e70039.
DOI: 10.1002/jbt.70039
Abstrakt: The purpose of this research was to provide light on the functional role that the long noncoding RNA SPACA6P-AS plays in the biology of colorectal cancer (CRC). The presence of elevated SPACA6P-AS expression in colorectal cancer tissues is linked to advanced stages of the disease as well as a decreased overall survival rate. It has been demonstrated through knockdown tests conducted on CRC cell lines that SPACA6P-AS stimulates cell growth in both in vitro and in vivo settings. By acting as a competing endogenous RNA, SPACA6P-AS is able to modulate the levels of miR-339-5p and promote the proliferation of colorectal cancer cells by way of the miR-339-5p/FAM167AFAM167A signaling axis. Based on these findings, SPACA6P-AS is a promising candidate for both a prognostic marker and a therapeutic target in colorectal cancer.
(© 2024 The Author(s). Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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