Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers.

Autor: Chadda KR; Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.; Homerton College, University of Cambridge, Cambridge, United Kingdom., Roberts SA; Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom., Lugg ST; Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom., Faniyi AA; Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom., Faustini SE; Clinical Immunology Service, Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom., Webster C; University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom., Duffy JE; University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom., Hewison M; Department of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom., Shields A; Clinical Immunology Service, Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom., Richter AG; Clinical Immunology Service, Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom., Parekh D; Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.; University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom., Scott A; Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom., Thickett DR; Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom.
Jazyk: angličtina
Zdroj: Frontiers in medicine [Front Med (Lausanne)] 2024 Nov 25; Vol. 11, pp. 1494129. Date of Electronic Publication: 2024 Nov 25 (Print Publication: 2024).
DOI: 10.3389/fmed.2024.1494129
Abstrakt: Objectives: Vitamin D has a role in the innate immunity against pathogens and is also involved in mechanisms for reducing inflammation. VD deficiency (VDD) may increase COVID-19 infection susceptibility, however research is limited on the association between VDD and COVID-19 symptom prevalence and duration. The study aimed to determine whether VDD is a risk factor for the presence and extended duration of COVID-19 symptoms.
Methods: Data was analyzed from NHS healthcare workers who isolated due to COVID-19 symptoms as a part of the COVID-19 convalescent immunity study between 12th to 22nd May 2020. Participants self-reported the presence and duration of viral symptoms. Anti-SARS-CoV-2 antibodies and vitamin D (25(OH)D 3 ) serum levels were measured on day of recruitment. VDD was defined as 25(OH)D 3 levels of < 30 nmol/l.
Results: Of the 392 participants, 15.6% ( n = 61) had VDD. VDD participants had more symptoms overall ( p = 0.0030), including body aches ( p = 0.0453), and extended duration of body aches ( p = 0.0075) and fatigue ( p = 0.0127). Binary logistic regression found that both VDD (OR 3.069, 95% CI 1.538-6.124; p = 0.001) and age (OR 1.026, 95% CI 1.003-1.049; p = 0.025) were independently associated with extended durations of body aches. VDD (OR 2.089, 95% CI 1.087-4.011; p = 0.027), age (OR 1.036, 95% CI 1.016-1.057; p < 0.001) and seroconversion (OR 1.917, 95% CI 1.203-3.056; p = 0.006), were independently associated with extended durations of fatigue.
Conclusion: VDD is a significant independent risk factor for extended durations of body aches and fatigue in healthcare workers who isolated for COVID-19 viral symptoms. Vitamin D supplementation may reduce symptom duration and is thus an area for future research.
Competing Interests: MH reports personal fees from Thornton Ross, outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Chadda, Roberts, Lugg, Faniyi, Faustini, Webster, Duffy, Hewison, Shields, Richter, Parekh, Scott and Thickett.)
Databáze: MEDLINE
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