Efficiency of gene therapy for sensorineural hearing loss in mouse model: A meta-analysis.

Autor: Yilmaz NK; Department of Internal Medicine Faculty of Veterinary Medicine, Ankara University Ankara Turkey.; Department of Otolaryngology Head & Neck Surgery University of Minnesota Minneapolis Minnesota USA., Ozen D; Department of Biostatistics Faculty of Veterinary Medicine, Ankara University Ankara Turkey., da Costa Monsanto R; Department of Otolaryngology Head & Neck Surgery University of Minnesota Minneapolis Minnesota USA., Ocak E; Department of Otolaryngology Head & Neck Surgery Faculty of Medicine, Ankara University Ankara Turkey., Schuster AK; Postgraduate Program in Medicine: Surgical Sciences, Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre RS Brazil., Shimura T; Department of Otolaryngology Head & Neck Surgery University of Minnesota Minneapolis Minnesota USA.; Department of Otorhinolaryngology Showa University Fujigaoka Hospital Yokohama Japan., Cureoglu S; Department of Otolaryngology Head & Neck Surgery University of Minnesota Minneapolis Minnesota USA.
Jazyk: angličtina
Zdroj: Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2024 Dec 09; Vol. 9 (6), pp. e70048. Date of Electronic Publication: 2024 Dec 09 (Print Publication: 2024).
DOI: 10.1002/lio2.70048
Abstrakt: Objectives: Sensorineural hearing loss (SNHL) is a disorder characterized by the loss or impairment of cochlear hair cells or the auditory nerve. In recent years, gene therapy has emerged as a promising approach for SNHL treatment. The objective of this study is to evaluate the impact of gene therapy on the restoration or improvement of auditory function in mouse model with loss or impairment of hearing.
Methods: Studies with clear experimental designs, and auditory brainstem response (ABR) analysis as relevant outcome measures were included by searching PubMed, Scopus, and Web of Science databases. The PRISMA guideline was used for abstracting data and assessing data quality and validity. A quantitative synthesis was performed using a random effects model to examine the effect of gene therapy on auditory function in SNHL.
Results: Nine articles including 71 studies meeting the inclusion criteria were identified. These studies explored therapies targeting the TMC1, VGLUT3, USH1C, CLRN1, WHRN, and PJVK genes, with genetic material ranging from 1.8 × 10 11 and 1.4 × 10 14  gc/mL being delivered to the inner ear through round window membrane, cochleostomy, or posterior semicircular canal injection methods. The hearing test results showed a significant mean difference of 26.91 dB (95% CI: 22.01-31.85) in favor of the experimental group.
Conclusions: Although promising results have been obtained regarding the potential success of gene therapy in SNHL, further investigation is needed to explore the long-term effects of gene therapy, treatment response rates, and the relationships between different genetic mutation types.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.)
Databáze: MEDLINE
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