Severe bupropion intoxication successfully treated with resin adsorber haemoperfusion.

Autor: Wannakittirat A; Division of Nephrology, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.; Excellence Centre for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Wipattanakitcharoen A; Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology, Chulalongkorn University, Bangkok, Thailand., Tosamran S; Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Yimsangyad K; Excellence Centre for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology, Chulalongkorn University, Bangkok, Thailand., Chaijamorn W; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand., Lumlertgul N; Excellence Centre for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology, Chulalongkorn University, Bangkok, Thailand., Peerapornratana S; Excellence Centre for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology, Chulalongkorn University, Bangkok, Thailand.; Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Limotai C; Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Comprehensive Epilepsy Centre of Excellence, Division of Neurology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Srisawat N; Excellence Centre for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology, Chulalongkorn University, Bangkok, Thailand.; Academy of Science, Royal Society of Thailand, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2025 Jan; Vol. 30 (1), pp. e14417.
DOI: 10.1111/nep.14417
Abstrakt: Bupropion is used as smoking cessation drug and antidepressant. Drug overdose has multi-system involvement including neurotoxicity and cardiovascular collapse. Use of haemoperfusion in bupropion toxicity is generally not useful, however in life-threatening condition it could be a life saver. We reported a case of 30s male with bupropion overdose who ingested 29 tablets of 300-mg extended-release bupropion. The patient had status epilepticus with prolonged QTc interval. He remained unconscious with abnormal jerky movements despite multiple high dose antiepileptic drugs. A 4-h session of resin adsorber haemoperfusion was done with rapid improvement of consciousness within 24 h and seizure control confirmed by electroencephalogram. In severe cases with early presentation, haemoperfusion may be useful to prevent further toxicity.
(© 2024 Asian Pacific Society of Nephrology.)
Databáze: MEDLINE
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