Cell-free placental DNA: What do we really know?

Autor: Yuen N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Lemaire M; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada., Wilson SL; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
Jazyk: angličtina
Zdroj: PLoS genetics [PLoS Genet] 2024 Dec 09; Vol. 20 (12), pp. e1011484. Date of Electronic Publication: 2024 Dec 09 (Print Publication: 2024).
DOI: 10.1371/journal.pgen.1011484
Abstrakt: Cell-free placental DNA (cfpDNA) is present in maternal circulation during gestation. CfpDNA carries great potential as a research and clinical tool as it provides a means to investigate the placental (epi)genome across gestation, which previously required invasive placenta sampling procedures. CfpDNA has been widely implemented in the clinical setting for noninvasive prenatal testing (NIPT). Despite this, the basic biology of cfpDNA remains poorly understood, limiting the research and clinical utility of cfpDNA. This review will examine the current knowledge of cfpDNA, including origins and molecular characteristics, highlight gaps in knowledge, and discuss future research directions.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Yuen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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