Therapeutic effects of Huangqi formula (Eefooton) in chronic kidney disease: clinical research and narrative literature review.

Autor:	Lu KC; Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.; Division of Nephrology, Department of Medicine, Fu-Jen Catholic University Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City 24352, Taiwan., Wu SC; Wu San-Chiang Medical Clinic, Lingya District, Kaohsiung City 802014, Taiwan.; Division of Nephrology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Lingya District, Kaohsiung City 80284, Taiwan., Lu TC; Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Niaosong District, Kaohsiung 833, Taiwan., Tzeng IS; Department of Statistics, School of Business, National Taipei University, New Taipei, Taiwan., Kuo CE; Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Niaosong District, Kaohsiung 833, Taiwan.; School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Dashu District, Kaohsiung 840, Taiwan., Hung YC; Department of Chinese Medicine, National Yang Ming Chiao Tung University, Beitou District, Taipei 112304, Taiwan.; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Beitou District, Taipei 112304, Taiwan.; Department of Chinese Medicine, Taipei City Hospital, Linsen, Chinese Medicine, and Kunming Branch, Datong District, Taipei 103212, Taiwan., Wu SY; Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Niaosong District, Kaohsiung 833, Taiwan.; School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Dashu District, Kaohsiung 840, Taiwan., Chen TC; Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, Niaosong District, Kaohsiung 833, Taiwan., Tsai MK; Division of Nephrology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Lingya District, Kaohsiung City 80284, Taiwan., Chuang CK; Division of Nephrology, Chong Guang Hospital, Miaoli, Taiwan, Toufen City, Miaoli County 351, Taiwan., Hu WL; Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Niaosong District, Kaohsiung 833, Taiwan.; Kaohsiung Medical University College of Medicine, Kaohsiung, Taiwan, Shihcyuan, Sanmin District, Kaohsiung 807, Taiwan.; Fooyin University College of Nursing, Kaohsiung, Taiwan, Ta-liao District, Kaohsiung 831, Taiwan.
Jazyk:	angličtina
Zdroj:	Aging [Aging (Albany NY)] 2024 Dec 07; Vol. 16. Date of Electronic Publication: 2024 Dec 07.
DOI:	10.18632/aging.206170
Abstrakt:	Objective: The study aimed to assess the clinical effects of employing the Huangqi formula (Eefooton; EFT) for chronic kidney disease (CKD) treatment. A narrative literature review was undertaken to elucidate the specific ingredients of EFT and their potential impact on renal health. Methods: A retrospective observational study investigated EFT treatment in outpatients with stable CKD (stages 3B to 5) from March 2019 to March 2021. Patients received 20 mL of EFT thrice daily for 6 months, along with standard treatment. Control groups were matched to the EFT cohort. Regular assessments of renal, liver functions, and lipid profiles were conducted. Results: Serum creatinine (Cr) and eGFR levels consistently improved in stage 3B CKD patients at each follow-up visit. At 6 months, improvement in Cr and eGFR was observed for stage 4 and 5 CKD. Stage 3B CKD patients exhibited notable reductions in systolic blood pressure after 3 and 6 months of EFT treatment. Remarkably, a substantial decrease in HbA1C was noted in stage 4 CKD individuals after three months of therapy. Additionally, stage 4 CKD patients saw a significant reduction in LDL levels after both 3 and 6 months of EFT treatment. A literature review on EFT ingredients indicated that the positive effects of EFT might be associated with its anti-inflammatory, antioxidant, and anti-fibrotic properties. Conclusions: This research demonstrated that incorporating EFT alongside standard treatment enhanced renal function in individuals with CKD. EFT is proposed as a feasible complementary treatment for CKD patients, emphasizing the importance of early intervention.
Databáze:	MEDLINE
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