No Evidence of Interaction Between FADS2 Genotype and Breastfeeding on Cognitive or Other Traits in the UK Biobank.

Autor: Centorame G; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia. g.centorame@uq.edu.au.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. g.centorame@uq.edu.au.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. g.centorame@uq.edu.au., Warrington NM; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia.; Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.; Department of Public Health and Nursing, K. G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Wang G; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia., Davey Smith G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Evans DM; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Jazyk: angličtina
Zdroj: Behavior genetics [Behav Genet] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.
DOI: 10.1007/s10519-024-10210-0
Abstrakt: Breastfeeding is hypothesised to benefit child health and cognitive functioning by providing long-chain polyunsaturated fatty acids, which are essential for brain development. In 2007, Caspi et al. found evidence in two cohorts for an interaction between genetic variation in the FADS2 gene (a gene involved in fatty acid metabolism) and breastfeeding on IQ. However, subsequent studies have provided mixed evidence for the existence of an interaction. We investigated the relationship between genetic variation in the FADS2 region, breastfeeding, and their interaction in up to 335,650 individuals from the UK Biobank. We tested for the interaction over a range of cognitive functioning tests, as well as educational attainment and other traits thought to be influenced by breastfeeding, including cardiometabolic traits, number of offspring, and atopic allergy. FADS2 alleles associated with an increase in docosahexaenoic acid in blood serum (the C allele of rs174575) were associated with decreased verbal-numerical reasoning ( p = 2.28 × 10 - 5 ) and triglycerides ( p = 1.40 × 10 - 41 ), increased number of offspring ( p = 3.40 × 10 - 5 ), total cholesterol ( p = 5.28 × 10 - 36 ), HDL ( p = 1.42 × 10 - 51 ), and LDL cholesterol ( p = 1.46 × 10 - 21 ). We observed no evidence of an interaction in any of the traits, regardless of the modelling strategy on any cognitive or non-cognitive traits. We postulate that the previous positive findings are likely to be spurious, perhaps due to lack of appropriate control for latent population structure.
Competing Interests: Declarations. Conflict of interest: The authors have not disclosed any competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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