Exosomal MiRNA Therapy for Central Nervous System Injury Diseases.

Autor: Chang C; Guangxi University of Chinese Medicine, No. 179 Mingxiu East Road, Nanning, 530001, Guangxi, China., Weiping L; Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning, 530011, Guangxi, China., Jibing C; Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning, 530011, Guangxi, China. chenjb@gxtcmu.edu.cn.
Jazyk: angličtina
Zdroj: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2024 Dec 09; Vol. 45 (1), pp. 3. Date of Electronic Publication: 2024 Dec 09.
DOI: 10.1007/s10571-024-01522-0
Abstrakt: Central nervous system diseases include central nervous system injury diseases, neurodegenerative diseases, and other conditions. MicroRNAs (miRNAs) are important regulators of gene expression, with therapeutic potential in modulating genes, pathways, and cells associated with central nervous system injury diseases. This article comprehensively reviews the therapeutic role of exosomal miRNAs in various central nervous system injury diseases, including traumatic brain injury, ischemic stroke, intracerebral hemorrhage, optic nerve injury, and spinal cord injury. This review covers the pathophysiology, animal models, miRNA transfection, administration methods, behavioral tests for evaluating treatment efficacy, and the mechanisms of action of miRNA-based therapies. Finally, this article discusses the future directions of miRNA therapy for central nervous system injury diseases.
Competing Interests: Declarations. Competing Interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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