Asparagi radix alleviates testosterone-induced benign prostatic hyperplasia by inhibiting 5α-reductase activity and androgen receptor signaling pathway.

Autor:	Hwangbo H; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.; Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea., Cha HJ; Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49104, Korea., Kim MY; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.; Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea., Ji SY; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.; Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea., Kim DH; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.; Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea., Noh JS; Department of Food Science & Nutrition, Tongmyong University, Busan 48520, Korea., Kim TH; Hamsoapharm Central Research, Jinan 55442, Korea., Kim HS; Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 46241, Korea., Moon SK; Department of Food and Nutrition, Chung-Ang University, Ansung 17546, Korea., Kim GY; Department of Marine Life Science, Jeju National University, Jeju 63243, Korea., Choi YH; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.; Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center, Dong-eui University, Busan 47227, Korea.
Jazyk:	angličtina
Zdroj:	Nutrition research and practice [Nutr Res Pract] 2024 Dec; Vol. 18 (6), pp. 793-805. Date of Electronic Publication: 2024 Aug 19.
DOI:	10.4162/nrp.2024.18.6.793
Abstrakt:	Background/objectives: Recently, herbal medicines have gained attention for the treatment of benign prostatic hyperplasia (BPH), a common disease in elderly men. In this study, we aimed to determine the effect of ethanol extract of Asparagi radix (EAR), which is traditionally used to treat various diseases, on BPH development using a testosterone-induced BPH model. Materials/methods: Testosterone propionate (TP)-treated Sprague-Dawley rats were used to establish a BPH model in vivo . EAR was orally administered along with TP, and finasteride was used as a positive control. All rats were sacrificed at the end of the experiment, and pathological changes in the prostate tissue and levels of key biomarkers associated with BPH pathogenesis were assessed. Results: Oral administration of EAR significantly inhibited TP-induced BPH by reducing the prostate weight, lumen size, and epithelial thickness in a concentration-dependent manner. EAR also significantly abrogated the expression of 5α-reductase type 2 (SRD5A2), proliferating cell nuclear antigen, and prostate-specific antigen (PSA) induced by TP. Additionally, serum levels of testosterone, dihydrotestosterone, and PSA were elevated in the TP-induced group but decreased in the EAR-treated group. EAR also decreased the expression levels of the androgen receptor (AR) and its coactivators in TP-induced BPH model rats. Conclusion: Our findings revealed that EAR protected against BPH by inhibiting 5α-reductase activity and AR signaling pathway, suggesting its potential for BPH treatment. Competing Interests: Conflict of Interest: The authors declare no potential conflicts of interests. (©2024 The Korean Nutrition Society and the Korean Society of Community Nutrition.)
Databáze:	MEDLINE
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