Prevalence of bacteriuria and treatment outcomes in patients with symptomatic benign prostatic hyperplasia: a prospective observational study.

Autor:	Ramdam N; Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan., Upadhya PS; Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan., Luitel P; Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Thapaliya I; Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Paudel S; Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Kashyap S; Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan., Karkee RJ; Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan., Gupta RK; Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Oct 16; Vol. 86 (12), pp. 6997-7001. Date of Electronic Publication: 2024 Oct 16 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000002670
Abstrakt:	Introduction: The global incidence of benign prostatic hyperplasia (BPH) is rising, with bacterial causes of lower urinary tract symptoms (LUTS) being a common factor contributing to complications in these patients. Aim: To identify the prevalence of bacteriuria and treatment response in patients with symptomatic BPH. Materials and Methods: This 1-year prospective study included all patients presenting with LUTS due to BPH who met the inclusion criteria. Urine samples were collected and analyzed for microscopy, culture, and sensitivity following standard protocols. Bacterial growth in urine specimens and International Prostate Symptom Score (IPSS) of LUTS were recorded before and after antibiotic therapy. Results: A total of 131 patients with symptomatic BPH were studied. Escherichia coli (47.6%) was the most commonly isolated bacteria, followed by Klebsiella pneumoniae and Pseudomonas species. E. coli and Klebsiella showed the highest sensitivity to nitrofurantoin. After 1 week of antibiotic therapy, 69% of patients had sterile urine cultures, while 31% remained E. coli positive. Significant improvement in IPSS scores was observed after 1 week of therapy ( P <0.05), and there was no significant change in urine culture ( P =0.854). Conclusion: Bacteriuria is a common finding in patients with symptomatic BPH in our setting. Escherichia coli and Klebsiella pneumoniae were the most frequently isolated organisms, with sensitivity to nitrofurantoin and cefixime. A week of antibiotic therapy significantly reduced IPSS scores but did not reduce bacteriuria. Competing Interests: The authors declare no conflict of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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