Exploring the association between atrial fibrillation and celiac disease: a comprehensive review.
| Autor: | Subedi R; Universal College of Medical Sciences, Siddharthanagar., Soulat A; Ziauddin Medical University., Rauf Butt S; University College of Medicine and Dentistry., Mohan A; Karachi Medical & Dental College., Danish Butt M; C.M.H. Lahore Medical College, Lahore, Pakistan., Arwani S; Medway Maritime Hospital, Gillingham, UK., Ahmed G; Dow Medical College., Majumder K; Chittagong Medical College, Chittagong, Bangladesh., Mohan Lal P; Ziauddin University., Kumar V; The Brooklyn Hospital Center, Brooklyn, NY., Tejwaney U; Valley Health System, Ridgewood, NJ., Ram N; Aga Khan University Hospital, Karachi., Kumar S; Wayne State University, Detroit, MI, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Jun 10; Vol. 86 (12), pp. 7155-7163. Date of Electronic Publication: 2024 Jun 10 (Print Publication: 2024). |
| DOI: | 10.1097/MS9.0000000000002259 |
| Abstrakt: | Objective: This paper aims to provide a comprehensive overview of the pathophysiology of atrial fibrillation (AF) and celiac disease (CD) individually while also exploring the emerging evidence of a potential association between the two conditions. Methods: The pathophysiology of AF, the most prevalent arrhythmia globally, and CD, an autoimmune condition triggered by gluten consumption, is examined. Genetic, structural, electrophysiological, and inflammatory factors contributing to their development are explored. Results: AF involves irregular atrial activity leading to electrical and structural remodeling of the atrium. CD is characterized by an immune response to gluten, primarily associated with HLA-DQ2 and HLA-DQ8 genetic mutations, resulting in damage to intestinal tissue. Emerging research suggests a link between AF and CD, possibly mediated through inflammation, fibrosis, and electromechanical delays in the atrium. Conclusion: Understanding the association between AF and CD carries significant clinical implications. Recognition of this relationship can assist in identifying individuals at higher risk for AF and inform proactive management strategies. Additionally, it underscores the importance of comprehensive care for CD patients, considering potential cardiac implications. Further research is warranted to elucidate precise mechanisms and explore potential therapeutic interventions targeting common pathways, opening avenues for enhanced patient care and future investigations. Competing Interests: No conflict of interest declared.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| Databáze: | MEDLINE |
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