The diagnostic challenge of differentiating tumefactive multiple sclerosis (TMS) from other brain lesions: a case report and literature review on a rare subtype of MS.

Autor:	Gill A; Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan., Eltawansy S; Department of Internal Medicine, Jersey Shore University Medical Center, Neptune, New Jersey, USA., Karamat RI; Rahbar Medical and Dental College, Lahore, Pakistan., Nadeem ZA; Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan., Esposito S; Department of Neurosurgery, Mayo Clinic Hospital, Phoenix, Arizona., Karamat SI; Rashid Latif Medical and Dental College, Lahore, Pakistan., Aamir M; Dow Medical College, Karachi, Pakistan., Anwaar A; Midcity Hospital, Lahore, Pakistan., Akilimali A; Medical Research Circle (MedReC), Goma, DR Congo.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Oct 24; Vol. 86 (12), pp. 7418-7422. Date of Electronic Publication: 2024 Oct 24 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000002687
Abstrakt:	Introduction and Importance: This case report is a clinical diagnosis walk through of a rare subtype of multiple sclerosis (MS). It gives an overview of how tumefactive multiple sclerosis (TMS) is systematically narrowed down as the definitive diagnosis. Case Presentation: This 29-year-old male patient presented to the emergency department. He collapsed after experiencing pain over his right frontotemporal region followed by a seizure witnessed by his family. Magnetic Resonance Imaging of the brain displayed diffuse enlargement and abnormal T2 weighted and FLAIR hyperintense signals in the diagnostic impressions described by the radiologist of the right temporoparietal region. Clinical Discussion: Liquefactive multiple sclerosis, also known as tumefactive multiple sclerosis or Marburg-type multiple sclerosis, is a rare subtype of the neurological disorder that can be difficult to diagnose. Unlike the traditional form of MS, TMS can present as a brain tumor and must be diagnosed with a biopsy rather than via MRI and clinical findings alone. Patients can typically present with headache, cognitive abnormalities, mental confusion, aphasia, apraxia, seizures, and weakness. Here, the authors discuss the presentation, disease diagnosis process and patient management. Conclusion: The patient was stabilized and discharged with a referral to the neurosurgery and neurology departments for outpatient consultation for future clinical management and treatment of their condition. Competing Interests: The authors declare no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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