Smart PDOs™ and the Cartesian Technique™: A milestone in facial rejuvenation with bioactive scaffolds.
| Autor: | Velazco de Maldonado GJ; Latin American Center for Research and Training in Minimally Invasive Surgery Foundation, Bogotá, Colombia., Suarez-Vega DV; Department of Research, Dental Research Center, Faculty of Dentistry, University of Los Andes, Mérida, Venezuela., Miller-Kobisher B; Department of Academic Research, Pan American Institute of Scientific Professionals, Mexico City, Mexico., Víctor GG; Department of Academic Research, Foundation Center for Aesthetic Medicine Studies, Caracas, Venezuela. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cutaneous and aesthetic surgery [J Cutan Aesthet Surg] 2024 Oct-Dec; Vol. 17 (4), pp. 292-306. Date of Electronic Publication: 2024 Oct 21. |
| DOI: | 10.25259/jcas_191_22 |
| Abstrakt: | Objectives: Evaluate the controlled release of silicon from smart polydioxanone suture (Smart PDOs™) and the clinical effect of the Cartesian Technique™ in face lifting. Material and Methods: This study was preclinical and clinical trials randomized, uncontrolled, and phase I carried out. Preclinical trials included instrumental analysis of silicon-enriched sutures by light microscopy, electron microscopy, and Ultraviolet-visible (UV-vis) spectroscopy. The clinical trial included 35 patients with primary and secondary rhytides, grade I lipomatosis, and grade I deflation. Polydioxanone (PDO) sutures are inserted following the Cartesian Technique™, a vectorial lift from the intersection of the Cartesian planes of the face. Once the cannulas were inserted with the PDO thread, 0.1 mL of organic silicon was dosed. Turgidity was examined by the pinch test of skin turgor. To measure the position of flaccid or deflated tissues, the scale used was the deflation scale. Results: The controlled release of organic silicon from the PDO sutures was verified. Its clinical application revealed that after 8 days the improvement in turgidity, wrinkle reversal, and flaccidity tightening was maintained in 100% of the sample. At 15 days, reversal of rhytides was observed, softening of deep furrows in 80%, and the initial turgor and skin tightening maintained without deflation in 90% of cases. Histopathological findings reveal that silicon synergistically potentiates the tissue effect of the PDO suture, generating greater biostimulation of fibroblasts with better quality collagen fibers, greater restructuring and redensification of the skin, and avoiding the late inflammatory response. Conclusion: The Cartesian Technique™ with Smart PDOs™ is an effective protocol for skin replenishment that enhances cell biostimulation through the release of bioactive drugs. Competing Interests: There are no conflicts of interest. (© 2024 Published by Scientific Scholar on behalf of Journal of Cutaneous and Aesthetic Surgery.) |
| Databáze: | MEDLINE |
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