Histopathology of Allograft Nephrectomies - A Ten Year Observational Study.
| Autor: | Malathi CV; Department of Pathology, Renopath Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India., Jansi Prema KS; Department of Pathology, Renopath Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India., Kurien AA; Department of Pathology, Renopath Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India. |
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| Jazyk: | angličtina |
| Zdroj: | Indian journal of nephrology [Indian J Nephrol] 2024 Nov-Dec; Vol. 34 (6), pp. 617-622. Date of Electronic Publication: 2024 Jul 22. |
| DOI: | 10.25259/IJN_73_2024 |
| Abstrakt: | Background: Though infrequent, allograft nephrectomies are performed for early and late graft loss. The study aims to analyze the histopathologic characteristics of allograft nephrectomy specimens. Materials and Methods: We conducted an observational study of 103 cases of allograft nephrectomies from 21 centers from 2013 to 2023. All the pathology slides, including hematoxylin and eosin-stained sections, masson trichrome, jones methenamine silver, PAS, GMS, AFB, and immunohistochemistry (C4d, SV40) were reviewed. Pathologic findings were analyzed based on the transplant to nephrectomy interval (0-3 months, > 3 months) and type of donor (deceased, live donor). Results: Of the total 103 cases, 77 were male. The mean age at the time of nephrectomy was 36.4 (range 5-64) years. The allografts were obtained from deceased (57) donors and live related (46) donors. Graft tenderness, oliguria/anuria, and fever were common clinical presentations. The majority (71.8%) of the nephrectomies were performed within the first 3 months of renal transplant. Renal vessel thrombosis (32.03%) was the most common pathologic finding. Infections were more common in the first 3 months after the transplant. Fungal infection had a significant association with deceased donor transplantation (p = 0.029). Conclusion: Histopathological study of allograft nephrectomy specimens aids understanding of graft loss causes. The study also provides opportunities to prevent complications and implement measures to prolong graft survival in a subsequent transplant. Competing Interests: There are no conflicts of interest. (© 2024 Indian Journal of Nephrology | Published by Scientific Scholar.) |
| Databáze: | MEDLINE |
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