How to preserve the native or reconstructed esophagus after perforations or postoperative leaks: A multidisciplinary 15-year experience.

Autor:	Nachira D; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy. dania.nachira@policlinicogemelli.it., Calabrese G; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Senatore A; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Pontecorvi V; Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Kuzmych K; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Belletatti C; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Boskoski I; Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Università Cattolica del Sacro Cuore di Roma, Center for Endoscopic Research Therapeutics and Training, Rome 00168, Italy., Meacci E; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Biondi A; General Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome 00168, Italy., Raveglia F; Department of Thoracic Surgery, IRCCS-San Gerardo dei Tintori, Monza 20900, Lombardy, Italy., Bove V; Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Congedo MT; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Vita ML; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Santoro G; Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome 00168, Italy., Petracca Ciavarella L; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Lococo F; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Punzo G; Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Lazio, Italy., Trivisonno A; Department of Plastic Surgery, Assunzione di Maria Santissima Clinic, Rome 00135, Italy., Petrella F; Department of Thoracic Surgery, IRCCS-San Gerardo dei Tintori, Monza 20900, Lombardy, Italy., Barbaro F; Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., Spada C; Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy., D'Ugo D; Department of Surgery, 'Agostino Gemelli' University Hospital, Catholic University of Rome, Rome 00168, Italy., Cioffi U; Department of Surgery, University of Milan, Milan 20122, Italy., Margaritora S; Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Jazyk:	angličtina
Zdroj:	World journal of gastrointestinal surgery [World J Gastrointest Surg] 2024 Nov 27; Vol. 16 (11), pp. 3471-3483.
DOI:	10.4240/wjgs.v16.i11.3471
Abstrakt:	Background: Esophageal perforation or postoperative leak after esophageal surgery remain a life-threatening condition. The optimal management strategy is still unclear. Aim: To determine clinical outcomes and complications of our 15-year experience in the multidisciplinary management of esophageal perforations and anastomotic leaks. Methods: A retrospective single-center observational study was performed on 60 patients admitted at our department for esophageal perforations or treated for an anastomotic leak developed after esophageal surgery from January 2008 to December 2023. Clinical outcomes were analyzed, and complications were evaluated to investigate the efficacy and safety of our multidisciplinary management based on the preservation of the native or reconstructed esophagus, when feasible. Results: Among the whole series of 60 patients, an urgent surgery was required in 8 cases due to a septic state. Fifty-six patients were managed by endoscopic or hybrid treatments, obtaining the resolution of the esophageal leak/perforation without removal of the native or reconstructed esophagus. The mean time to resolution was 54.95 ± 52.64 days, with a median of 35.5 days. No severe complications were recorded. Ten patients out of 56 (17.9%) developed pneumonia that was treated by specific antibiotic therapy, and in 6 cases (10.7%) an atrial fibrillation was recorded. Seven patients (12.5%) developed a stricture within 12 months, requiring one or two endoscopic pneumatic dilations to solve the problem. Mortality was 1.7%. Conclusion: A proper multidisciplinary approach with the choice of the most appropriate treatment can be the key for success in managing esophageal leaks or perforations and preserving the esophagus. Competing Interests: Conflict-of-interest statement: Boskoski I is consultant for Apollo Endosurgery, Boston Scientific, Cook Medical, Nitinotes, Erbe Elektromedizin, Pentax Medical, Fractyl Health, and Lecturer for Microteach. All the other authors report no relevant conflicts of interest for this article. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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