Multiscale optoacoustic assessment of skin microvascular reactivity in carotid artery disease.

Autor:	Karlas A; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Germany.; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany.; Chair for Computer Aided Medical Procedures & Augmented Reality, Technical University of Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner Site Munich Heart Alliance, Munich, Germany., Katsouli N; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Germany.; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany., Fasoula NA; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Germany.; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany., Reidl M; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Germany.; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany., Lees R; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Germany.; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany., Zang L; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Carrillo MDPO; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Saicic S; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Schäffer C; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Hadjileontiadis L; Department of Biomedical Engineering & Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, UAE.; Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece., Branzan D; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Ntziachristos V; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Germany.; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner Site Munich Heart Alliance, Munich, Germany., Eckstein HH; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Kallmayer M; Clinic and Polyclinic for Vascular and Endovascular Surgery, TUM University Hospital, Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
Jazyk:	angličtina
Zdroj:	Photoacoustics [Photoacoustics] 2024 Oct 30; Vol. 40, pp. 100660. Date of Electronic Publication: 2024 Oct 30 (Print Publication: 2024).
DOI:	10.1016/j.pacs.2024.100660
Abstrakt:	Microvascular endothelial dysfunction may provide insights into systemic diseases, such as carotid artery disease. Raster-scan optoacoustic mesoscopy (RSOM) can produce images of skin microvasculature during endothelial dysfunction challenges via numerous microvascular features. Herein, RSOM was employed to image the microvasculature of 26 subjects (13 patients with single carotid artery disease, 13 healthy participants) to assess the dynamics of 18 microvascular features at three scales of detail, i.e., the micro- (<100 μm), meso- (≈100-1000 μm) and macroscale (<1000 μm), during post-occlusive reactive hyperemia challenges. The proposed analysis identified a subgroup of 9 features as the most relevant to carotid artery disease because they achieved the most efficient classification (AUC of 0.93) between the two groups in the first minute of hyperemia (sensitivity/specificity: 0.92/0.85). This approach provides a non-invasive solution to microvasculature quantification in carotid artery disease, a main form of cardiovascular disease, and further highlights the possible link between systemic disease and microvascular dysfunction. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Vasilis Ntziachristos reports a relationship with sThesis GmbH that includes: equity or stocks. Vasilis Ntziachristos reports a relationship with iThera Medical GmbH that includes: equity or stocks. Vasilis Ntziachristos reports a relationship with I3 Inc that includes: equity or stocks. Vasilis Ntziachristos reports a relationship with Spear UG that includes: equity or stocks. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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