Transcranial direct current stimulation (tDCS) enhances cognitive function in schizophrenia: A randomized double-blind sham-controlled trial.

Autor: García-Fernández L; Clinical Medicine Department, Universidad Miguel Hernández, Investigador. Cibersam isciii, Crta. Nacional 332 s/n, Alicante 03550, Spain; Psychiatry Department, Hospital Universitario de San Juan, Alicante, Spain; CIBERSAM-ISCIII (Biomedical Research Networking Centre for Mental Health), Spain. Electronic address: lorena.garciaf@umh.es., Romero-Ferreiro V; CIBERSAM-ISCIII (Biomedical Research Networking Centre for Mental Health), Spain; European University of Madrid, Madrid, Spain; Health Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain., Padilla S; Clinical Medicine Department, Universidad Miguel Hernández, Investigador. Cibersam isciii, Crta. Nacional 332 s/n, Alicante 03550, Spain; Infectious Diseases Unit, Hospital General Universitario de Elche, Alicante, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Wynn R; Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway; Department of Education, ICT and Learning, Østfold University College, Halden, Norway., Pérez-Gálvez B; Clinical Medicine Department, Universidad Miguel Hernández, Investigador. Cibersam isciii, Crta. Nacional 332 s/n, Alicante 03550, Spain; Psychiatry Department, Hospital Universitario de San Juan, Alicante, Spain., Álvarez-Mon MÁ; Department of Medicine and Medical Specialities. University of Alcala, Alcala de Henares, Spain; Department of Psychiatry and Mental Health. Hospital Universitario Infanta Leonor, Madrid, Spain; Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid 28034, Spain., Sánchez-Cabezudo Á; Health Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain., Rodriguez-Jimenez R; CIBERSAM-ISCIII (Biomedical Research Networking Centre for Mental Health), Spain; Health Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain; Complutense University of Madrid (UCM), Madrid, Spain.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2024 Dec 02; Vol. 344, pp. 116308. Date of Electronic Publication: 2024 Dec 02.
DOI: 10.1016/j.psychres.2024.116308
Abstrakt: This study aimed to examine the cognitive effects of tDCS and the subjective cognitive improvement perceived by patients with schizophrenia. A total of 173 outpatients diagnosed with schizophrenia were recruited for this double-blind, randomized, placebo-controlled trial. Two different stimulation modes were applied: 2 mA 20 minutes active tDCS and sham tDCS. Ten daily sessions over 10 consecutive weekdays were applied, using a bifrontal montage (F3/F4). The Positive and Negative Syndrome Scale for Schizophrenia and the MATRICS Consensus Cognitive Battery (MCCB) were administered at baseline. The MCCB and a scale designed for measuring subjective cognitive improvement were administered to evaluate the outcomes. Post hoc comparisons revealed significant effects between the two types of interventions in Working Memory (EMM difference = 2.716, p < .001) and Neurocognition (EMM difference = 1.289, p = .007. Chi-squared tests demonstrated a significant association between subjective improvement and the treatment group, χ² (2) = 10.413, p = .005, Cramer's V = 0.295. A higher proportion of patients in active tDCS (68.6%) reported cognitive improvement compared to sham tDCS (31.4%). We concluded that tDCS can enhance cognition and generate a satisfactory perception of cognitive improvement in patients with schizophrenia.
Competing Interests: Declaration of competing interest Dr. R. Rodriguez-Jimenez has been a consultant for, spoken in activities of, or received grants from: Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid Regional Government (S2010/ BMD-2422 AGES; S2017/BMD-3740; P2022/BMD-7216), JanssenCilag, Lundbeck, Otsuka, Pfizer, Ferrer, Juste, Takeda, Exeltis, Casen-Recordati, Angelini, Rovi. All other authors declare that they have no competing interests.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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