The influence of microorganisms on bone homeostasis in apical periodontitis.

Autor: Pan D; West China School of Stomatology (WCSS), Sichuan University, No. 14, Section 3, Renmin Nanlu, Chengdu 610041, China; West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address: pd28972024@163.com., Hao Y; West China School of Stomatology (WCSS), Sichuan University, No. 14, Section 3, Renmin Nanlu, Chengdu 610041, China; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Stomatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address: 546894417@qq.com., Tao Y; West China School of Stomatology (WCSS), Sichuan University, No. 14, Section 3, Renmin Nanlu, Chengdu 610041, China; West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address: yuyan_tao2024@163.com., Li B; West China School of Stomatology (WCSS), Sichuan University, No. 14, Section 3, Renmin Nanlu, Chengdu 610041, China; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address: li-bolei@qq.com., Cheng L; West China School of Stomatology (WCSS), Sichuan University, No. 14, Section 3, Renmin Nanlu, Chengdu 610041, China; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address: chengleidentist@163.com.
Jazyk: angličtina
Zdroj: Archives of oral biology [Arch Oral Biol] 2024 Nov 30; Vol. 170, pp. 106153. Date of Electronic Publication: 2024 Nov 30.
DOI: 10.1016/j.archoralbio.2024.106153
Abstrakt: Objective: This review aims to provide an overview of the role of microorganisms in the onset and progression of periapical diseases, particularly regarding their effects on bone homeostasis.
Design: The search for this narrative review was conducted in PubMed, Web of Science and Google Scholar using relevant keywords, including checking reference lists of journal articles by hand searching.
Results: Microorganisms directly promote osteoclasts through pathways such as nuclear factor-κB (NF-κB) and extracellular regulated protein kinases (ERK), while inhibiting osteoblasts function by interfering with the wingless-related integration site (Wnt)/β-catenin pathway in the periapical area. Moreover, microorganisms indirectly regulate periapical bone homeostasis by inducing programmed cell death and modulating the immune microenvironment through the activation of innate immunity via pattern-recognition receptors (PRRs) and subsequent cascades of responses. Among these microorganisms, Enterococcus faecalis, Porphyromonas gingivalis and Fusobacterium nucleatum play significant roles.
Conclusion: Microorganisms regulate pathways such as NF-ĸB and Wnt/β-catenin, as well as programmed cell death and the immune microenvironment in the periapical area, thereby disrupting bone homeostasis.
Competing Interests: Declaration of Competing Interest All the authors declare that they have no competing interests in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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