Identification of differentially expressed miRNAs involved in vascular aging reveals pathways associated with the endocrine hormone regulation.

Autor: Jeon J; Division of Applied Life Science, Gyeongsang National University, Jinju, Republic of Korea.; Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju, Republic of Korea., Jang S; Division of Applied Life Science, Gyeongsang National University, Jinju, Republic of Korea.; Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju, Republic of Korea., Park KS; Department of Preventive Medicine, College of Medicine and Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea.; Center for Farmer's Safety and Health, Gyeongsang National University Hospital, Jinju, Republic of Korea., Kim HG; Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea., Lee J; Animal Genomics and Bioinformatics Division, National Institute of Animal Science, Rural Development Administration, Wanju, 55365, Republic of Korea., Hwang TS; College of Veterinary Medicine, Gyeongsang National University, Jinju, 52828, Republic of Korea., Koh JS; Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea. jskoh@gnu.ac.kr., Kim J; Division of Applied Life Science, Gyeongsang National University, Jinju, Republic of Korea. jmkim85@gnu.ac.kr.; Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju, Republic of Korea. jmkim85@gnu.ac.kr.
Jazyk: angličtina
Zdroj: Biogerontology [Biogerontology] 2024 Dec 07; Vol. 26 (1), pp. 23. Date of Electronic Publication: 2024 Dec 07.
DOI: 10.1007/s10522-024-10167-x
Abstrakt: Vascular aging refers to a series of processes where the elasticity of blood vessels diminishes, leading to stiffening, and deposition of fat components on the vessel walls, causing inflammation. Cardiovascular diseases, such as stroke and hypertension, play significant roles in morbidity and mortality rates among the elderly population. In this study, the Reactive Hyperemia Index (RHI) was measured to assess vascular endothelial function and aging-induced pathogenesis of vascular diseases in Korean subjects. We aimed to identify extracellular vesicle microRNAs (EV-miRNAs) with differential abundance between groups of individuals at the ends of a continuum in vascular aging acceleration, revealing miRNAs regulating genes in endocrine hormone regulation and tumor-related pathways. We also discovered that the principal component characterizing the global miRNA expression profile is significantly associated with clinical traits including cholesterol levels. Together, these data provide a foundation for understanding the role of miRNAs as modulators of longevity and for developing age-specific epigenetic biomarkers.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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