| Autor: |
Dawoud A; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt.; School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Youness RA; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt.; Molecular Biology and Biochemistry Department, Faculty of Biotechnology, German International University, Cairo, Egypt., Elsayed K; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt., Nafae H; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt., Allam H; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt.; Biochemistry Department, Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Giza, Egypt., Saad HA; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt., Bourquin C; School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University of Geneva, Geneva, Switzerland., Szabo C; Chair of Pharmacology, Section of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Abdel-Kader R; Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt., Gad MZ; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), New Cairo, Egypt. |
| Abstrakt: |
Gasotransmitters play crucial roles in regulating many physiological processes, including cell signaling, cellular proliferation, angiogenesis, mitochondrial function, antioxidant production, nervous system functions and immune responses. Hydrogen sulfide (H 2 S) is the most recently identified gasotransmitter, which is characterized by its biphasic behavior. At low concentrations, H 2 S promotes cellular bioenergetics, whereas at high concentrations, it can exert cytotoxic effects. Cystathionine β-synthetase (CBS), cystathionine-γ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (3-MST), and cysteinyl-tRNA synthetase 2 (CARS2) are pivotal players in H 2 S biosynthesis in mammalian cells and tissues. The focus of this review is the regulation of the various pathways involved in H 2 S metabolism in various forms of cancer. Key enzymes in this process include the sulfide oxidation unit (SOU), which includes sulfide:quinone oxidoreductase (SQOR), human ethylmalonic encephalopathy protein 1 (hETHE1), rhodanese, sulfite oxidase (SUOX/SO), and cytochrome c oxidase (CcO) enzymes. Furthermore, the potential role of H 2 S methylation processes mediated by thiol S-methyltransferase (TMT) and thioether S-methyltransferase (TEMT) is outlined in cancer biology, with potential opportunities for targeting them for clinical translation. In order to understand the role of H 2 S in oncogenesis and tumor progression, one must appreciate the intricate interplay between H 2 S-synthesizing and H 2 S-catabolizing enzymes. |
