Effects of flavonoids on yeast ABC transporters activity.

Autor: Grechko VM; Polessky State University, Pinsk, 225710, Belarus. Electronic address: Violetta.Korolevich@mail.ru., Cheshchevik VT; Polessky State University, Pinsk, 225710, Belarus., Dzeikala A; Lodz University of Technology, Łуdź, 90-530, Poland., Sykuła A; Lodz University of Technology, Łуdź, 90-530, Poland., Łodyga-Chruścińska E; Lodz University of Technology, Łуdź, 90-530, Poland.
Jazyk: angličtina
Zdroj: Fungal biology [Fungal Biol] 2024 Dec; Vol. 128 (8 Pt A), pp. 2231-2241. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1016/j.funbio.2024.09.004
Abstrakt: Flavonoids are known to be effective biomodulators of various processes in eukaryotic cells. As these compounds are present in wine and beer raw materials, they can influence the qualitative characteristics of the ethanol content in wine-making and brewing products, including directly through the mechanisms of regulation of gene expression and the activity of ATP-binding cassette (ABC) proteins. The main function of ABC transporters in yeast cells is to transport various substrates, including ethanol. This process ensures the survival of yeast cells under conditions of ethanol stress. It has been found that flavonoids, as well as their Schiff base derivatives, are effective stimulators and inhibitors of mRNA expression and activity of ABC proteins both in logarithmic and stationary phases of growth, which has a direct impact on bioethanol production by yeast.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 British Mycological Society. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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