The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7.

Autor:	Gelbard MK; Genetics, Molecular, and Cellular Biology Program, Graduate School of Biomedical Sciences, Tufts University, 02111, Boston, MA, USA; Department of Developmental, Molecular and Cellular Biology, Tufts University School of Medicine, 02111, Boston, MA, USA., Grace M; Department of Developmental, Molecular and Cellular Biology, Tufts University School of Medicine, 02111, Boston, MA, USA., von Schoeler-Ames A; Tufts University, MA, 02155, Medford, USA., Gnanou I; Emmanuel College, MA, 02115, Boston, USA., Munger K; Genetics, Molecular, and Cellular Biology Program, Graduate School of Biomedical Sciences, Tufts University, 02111, Boston, MA, USA; Department of Developmental, Molecular and Cellular Biology, Tufts University School of Medicine, 02111, Boston, MA, USA. Electronic address: Karl.Munger@tufts.edu.
Jazyk:	angličtina
Zdroj:	Tumour virus research [Tumour Virus Res] 2024 Dec 05; Vol. 19, pp. 200300. Date of Electronic Publication: 2024 Dec 05.
DOI:	10.1016/j.tvr.2024.200300
Abstrakt:	Human papillomaviruses (HPVs) are a diverse family of viruses with over 450 members that have been identified and fully sequenced. They are classified into five phylogenetic genera: alpha, beta, gamma, mu, and nu. The high-risk alpha HPVs, such as HPV16, have been studied the most extensively due to their medical significance as cancer-causing agents. However, while nearly 70% of all HPVs are members of the gamma genus, they are almost entirely unstudied. This is because gamma HPVs have been considered medically irrelevant commensals as most of them infect the skin and are not known to cause significant clinical lesions in immunocompetent individuals. Members of the gamma 6 HPVs, however, have been detected in the anogenital tract mucosa and HPV101 has been isolated from a premalignant cervical lesion. Moreover, gamma 6 HPVs have a unique genome structure. They lack E6 proteins but in place of E6, they encode unique, small hydrophobic proteins without any close viral or cellular homologs that have been termed E10. Here, we report that HPV101 E7 shares biochemical activities with the high-risk alpha HPV16 E7, including the ability to target the pRB and PTPN14 tumor suppressors for degradation. This study underscores the importance of further characterizing HPV101 and other unstudied HPV species. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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