Comparison of cortical gyrification patterns in patients with panic disorder with and without comorbid generalized anxiety disorder.

Autor: Moon J; Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Kim HJ; Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea., Song CR; Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea., Pae C; Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. Electronic address: paecw@chauniv.ac.kr., Lee SH; Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. Electronic address: drshlee@cha.ac.kr.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2024 Dec 04; Vol. 372, pp. 216-224. Date of Electronic Publication: 2024 Dec 04.
DOI: 10.1016/j.jad.2024.12.001
Abstrakt: Background: Lower functioning and higher symptom severity are observed when panic disorder (PD) co-occurs with generalized anxiety disorder (PD + GAD). No research on cortical gyrification patterns in the PD + GAD group has been conducted to date, which could show the alterations in brain connectivity in the extended fear network (EFN). This study aimed to investigate the characteristics of cortical gyrification in the PD + GAD group, compared to that in the PD without comorbid GAD (PD-GAD) group.
Methods: This study included 90 patients with PD, with propensity score matching between the PD + GAD (n = 30) and PD-GAD groups (n = 60), and 65 healthy controls (HC). For clinical evaluation, we assessed the anxiety symptomatology, suicidality, and harm avoidance. The local gyrification index (LGI) was obtained from T1-weighted brain MRI data using FreeSurfer.
Results: In the PD group compared to the HC, the hypergyrification involved the EFN. In the PD + GAD group compared to the PD-GAD group, hypergyrification was shown in the pathological worry-related brain regions. Within the PD + GAD group, significant positive correlations were observed between the superior frontal gyrus LGI values and suicidality scores, as well as between the superior parietal gyrus LGI values and harm avoidance levels.
Limitations: Given the variability in cortical gyrification patterns, longitudinal studies are needed to assess the occurrence of hypergyrification in specific brain regions.
Conclusions: This study is the first to demonstrate cortical gyrification patterns in the PD + GAD group compared to those in the PD-GAD group. Notably, the EFN and pathological worry-related brain regions have been implicated in the pathology of PD + GAD.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: