Ultrathin rubbery bio-optoelectronic stimulators for untethered cardiac stimulation.

Autor: Rao Z; Materials Research Laboratory, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.; Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA 16802, USA., Ershad F; Department of Electrical and Computer Engineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA., Guan YS; Institute of Advanced Materials, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, China., Paccola Mesquita FC; Regenerative Medicine Research Lab, Texas Heart Institute, Houston, TX 77030, USA., da Costa EC; Regenerative Medicine Research Lab, Texas Heart Institute, Houston, TX 77030, USA., Morales-Garza MA; Center for Preclinical Surgical & Interventional Research, Section of Transplantation, Texas Heart Institute, Houston, TX 77030, USA., Moctezuma-Ramirez A; Center for Preclinical Surgical & Interventional Research, Section of Transplantation, Texas Heart Institute, Houston, TX 77030, USA., Kan B; School of Materials Science and Engineering, Nankai University, Tianjin 300350, China., Lu Y; Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA 16802, USA., Patel S; Materials Research Laboratory, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA., Shim H; Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA 16802, USA.; Department of Electronics Engineering, Pusan National University, Busan 46241, Republic of Korea., Cheng K; Materials Science and Engineering Program, University of Houston, Houston, TX 77024, USA., Wu W; Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77024, USA., Haideri T; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA., Lian XL; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA., Karim A; Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77024, USA., Yang J; Department of Materials Science and Engineering, Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang 310030, China., Elgalad A; Center for Preclinical Surgical & Interventional Research, Section of Transplantation, Texas Heart Institute, Houston, TX 77030, USA., Hochman-Mendez C; Regenerative Medicine Research Lab, Texas Heart Institute, Houston, TX 77030, USA., Yu C; Materials Research Laboratory, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.; Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA 16802, USA.; Department of Electrical and Computer Engineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.; Department of Materials Science and Engineering, Materials Research Institute, Pennsylvania State University, University Park, PA 16802, USA.; Department of Mechanical Science and Engineering, Materials Science and Engineering, Bioengineering, Nick Holonyak Micro and Nanotechnology Laboratory, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Dec 06; Vol. 10 (49), pp. eadq5061. Date of Electronic Publication: 2024 Dec 06.
DOI: 10.1126/sciadv.adq5061
Abstrakt: Untethered electrical stimulation or pacing of the heart is of critical importance in addressing the pressing needs of cardiovascular diseases in both clinical therapies and fundamental studies. Among various stimulation methods, light illumination-induced electrical stimulation via photoelectric effect without any genetic modifications to beating cells/tissues or whole heart has profound benefits. However, a critical bottleneck lies in the lack of a suitable material with tissue-like mechanical softness and deformability and sufficient optoelectronic performances toward effective stimulation. Here, we introduce an ultrathin (<500 nm), stretchy, and self-adhesive rubbery bio-optoelectronic stimulator (RBOES) in a bilayer construct of a rubbery semiconducting nanofilm and a transparent, stretchable gold nanomesh conductor. The RBOES could maintain its optoelectronic performance when it was stretched by 20%. The RBOES was validated to effectively accelerate the beating of the human induced pluripotent stem cell-derived cardiomyocytes. Furthermore, acceleration of ex vivo perfused rat hearts by optoelectronic stimulation with the self-adhered RBOES was achieved with repetitive pulsed light illumination.
Databáze: MEDLINE