Women's healthcare providers' knowledge and practices surrounding fragile-X associated primary ovarian insufficiency (FXPOI).

Autor: Singleton AL; Department of Human Genetics, Emory University School of Medicine, 615 Michael St. Suite 301, Atlanta, GA, 30322, USA., Hipp HS; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA., Ali N; Department of Human Genetics, Emory University School of Medicine, 615 Michael St. Suite 301, Atlanta, GA, 30322, USA., Poteet B; Northside Hospital Cancer Institute, Atlanta, GA, USA., Allen EG; Department of Human Genetics, Emory University School of Medicine, 615 Michael St. Suite 301, Atlanta, GA, 30322, USA. emgrave@emory.edu.
Jazyk: angličtina
Zdroj: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.
DOI: 10.1007/s10815-024-03337-w
Abstrakt: Purpose: This study investigates the knowledge gaps about fragile X-associated primary ovarian insufficiency (FXPOI) among women's healthcare providers. Previous research highlighted a lack of awareness regarding FXPOI as a cause of primary ovarian insufficiency (POI) and its diagnosis. The objective of this study was to describe these gaps and explore demographic factors influencing FXPOI knowledge in women's healthcare practitioners.
Methods: A survey assessed familiarity with primary ovarian insufficiency and FXPOI knowledge among 107 women's healthcare providers and 14 medical students in the USA. Knowledge Scores, ranging from 0 to 16, were assigned, and demographic data, including healthcare provider type, specialty, and genetics exposure in education or training, were collected.
Results: Participants scored an average of 6.92 (± 2.19) out of 16 (42%) despite 88% of participants reporting genetics exposure in training. Maternal fetal medicine (MFM) and reproductive endocrinology (REI) providers significantly outperformed general obstetrics and gynecology (OBGYN) practitioners (p = 0.0186 and 0.0125, respectively). Participants with a genetic counselor in their clinic scored 8% higher (p = 0.0083) than those without. Additionally, medical school graduation year was a significant predictor for knowledge score (p = 0.0397).
Conclusion: This study underscores limited FXPOI knowledge among women's healthcare providers, aligning with patient reports. Notably, medical specialty and the presence of a genetic counselor impacted knowledge, emphasizing the urgency for broader education in women's healthcare, particularly among OBGYNs, the initial point of contact for patients with POI symptoms.
Competing Interests: Declarations. Conflict of interest: Alexandra Singleton, Heather Hipp, Bonnie Poteet and Emily Allen declare that they have no conflicts of interest. Nadia Ali has received research support from Sanofi Genzyme, Shire Takeda, BioMarin, Amicus, and Pfizer, as well as lecturers’ honoraria from Sanofi Genzyme, BioMarin, Amicus, and Vitaflo. These activities are monitored and in compliance with conflict of interest policies at Emory University.
(© 2024. The Author(s).)
Databáze: MEDLINE
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