The β 3 -Adrenergic Receptor: Structure, Physiopathology of Disease, and Emerging Therapeutic Potential.

Autor: Dongdem JT; Department of Chemical Pathology, School of Medicine, University for Development Studies, Tamale, Northern Region, Ghana.; Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale, Northern Region, Ghana., Etornam AE; Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale, Northern Region, Ghana., Beletaa S; Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale, Northern Region, Ghana., Alidu I; Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale, Northern Region, Ghana., Kotey H; Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale, Northern Region, Ghana., Wezena CA; Department of Microbiology, Faculty of Biosciences, University for Development Studies, Tamale, Northern Region, Ghana.
Jazyk: angličtina
Zdroj: Advances in pharmacological and pharmaceutical sciences [Adv Pharmacol Pharm Sci] 2024 Nov 28; Vol. 2024, pp. 2005589. Date of Electronic Publication: 2024 Nov 28 (Print Publication: 2024).
DOI: 10.1155/2024/2005589
Abstrakt: The discovery and characterization of the signal cascades of the β-adrenergic receptors have made it possible to effectively target the receptors for drug development. β-Adrenergic receptors are a class A rhodopsin type of G protein-coupled receptors (GPCRs) that are stimulated mainly by catecholamines and therefore mediate diverse effects of the parasympathetic nervous system in eliciting "fight or flight" type responses. They are detectable in several human tissues where they control a plethora of physiological processes and therefore contribute to the pathogenesis of several disease conditions. Given the relevance of the β-adrenergic receptor as a molecular target for many pathological conditions, this comprehensive review aims at providing an in-depth exploration of the recent advancements in β 3 -adrenergic receptor research. More importantly, we delve into the prospects of the β 3 -adrenergic receptor as a therapeutic target across a variety of clinical domains.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2024 Julius T. Dongdem et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje