Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition.

Autor:	Richard JM; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55415.; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415., Newell B; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55415.; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415., Muruganandan P; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55415.; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415., Janak PH; Department of Psychological and Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218.; The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21218., Saunders BT; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55415.; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415.
Jazyk:	angličtina
Zdroj:	Addiction neuroscience [Addict Neurosci] 2024 Dec; Vol. 13. Date of Electronic Publication: 2024 Nov 09.
DOI:	10.1016/j.addicn.2024.100186
Abstrakt:	Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously been established. Here, we tested the impact of optogenetic inhibition of ventral pallidum on Pavlovian-conditioned alcohol-seeking in male Long Evans rats. Rats underwent Pavlovian conditioning with an auditory cue predicting alcohol delivery to a reward port and a control cue predicting no alcohol delivery, until they consistently entered the reward port more during the alcohol cue than the control cue. We then tested the within-session effects of optogenetic inhibition during 50% of cue presentations. We found that optogenetic inhibition of ventral pallidum during the alcohol cue reduced port entry likelihood and time spent in the port, and increased port entry latency. Overall, these results suggest that normal ventral pallidum activity is necessary for Pavlovian alcohol-seeking. Competing Interests: Declaration of Interest: None.
Databáze:	MEDLINE
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