Management and outcomes of pediatric optic neuritis in a tertiary hospital in Riyadh, Saudi Arabia: a retrospective study.

Autor: Aldebasi T; Department of Ophthalmology, Ministry of National Guard Health Affairs, P O BOX 22490, Riyadh, 11426, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia., Altuwaijri W; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.; Department of Pediatrics, Ministry of National Guard- Health Affairs, Riyadh, Saudi Arabia., Gangadharan S; Department of Ophthalmology, Ministry of National Guard Health Affairs, P O BOX 22490, Riyadh, 11426, Saudi Arabia. shijisaj@rediffmail.com.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. shijisaj@rediffmail.com.; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. shijisaj@rediffmail.com., Alhammad D; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia., Alakel A; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia., Albekairy NA; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia., Badri M; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.; Department of Epidemiology and Biostatistics, College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: BMC neurology [BMC Neurol] 2024 Dec 05; Vol. 24 (1), pp. 474. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1186/s12883-024-03982-9
Abstrakt: Background: Although pediatric optic neuritis (PON) is a rare condition, current advancements in its diagnosis, investigation, and treatment suggest that a more precise risk assessment is necessary given the history of irreversible damage and functional degeneration of the optic nerve. Additionally, after further investigations and/or new neurological events, the initial diagnosis is revised.
Aim: To report clinical profile, management and outcome of different demyelinating disease phenotypes of pediatric optic neuritis (PON) in individuals under the age of 18 years in a tertiary center in the Kingdom of Saudi Arabia (KSA).
Study Method: We analyzed the electronic medical records of pediatric patients under the age of 18 years who first experienced different phenotypes of demyelinating PON between January 2000 and December 2020 as part of this retrospective case series. We studied the clinical characteristics, serology, imaging data, treatment regimens, and follow-up of the patients. Descriptive statistics were calculated.
Results: The majority of patients were less than 10 years old (63.6%), males (63.6%) and had bilateral involvement (72.7%). Among the 11 patients diagnosed with PON, 5(45.5%) had isolated pediatric optic neuritis, 1 (9.1%) had multiple sclerosis (MS), 1(9.1%) had neuromyelitis optica spectrum disorder (NMOSD), 1 (9.1%) had acute disseminated encephalomyelitis (ADEM) and 3 (27.2%) had myelin oligodendrocyte glycoprotein (MOG) antibody associated disease (MOGAD). Despite poor vision at presentation, most of the patients improved, 81.1% achieved a BCVA of ≥ 20/40, and 36.6% attained 20/20 visual acuity. Four patients experienced recurrence.
Conclusions: The overlapping features of disease phenotypes in PON make it difficult to identify the underlying cause. The findings of this retrospective case series suggest the need for a future prospective multicenter study for a better understanding of the different phenotypes.
Competing Interests: Declarations. Ethical approval: This study was approved by the King Abdullah International Medical Research (KAIMRC) ethics committee RC20/650/R. Consent for publication: Not applicable. Conflict of interest: The authors do not have any financial gains from the trademarks mentioned in the paper and do not have any conflicts of interest.
(© 2024. The Author(s).)
Databáze: MEDLINE
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