Low-grade systemic inflammation, but not neuroinflammation, is associated with 12-month postoperative outcome after total hip arthroplasty in patients with painful osteoarthritis.

Autor:	Blichfeldt-Eckhardt MR; Department of Anesthesiology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.; Pain Research Group, Department of Anesthesiology and Intensive Care Medicine, Odense University Hospital, Odense, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Varnum C; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Orthopaedic Surgery, Lillebaelt Hospital - Vejle, University Hospital of Southern Denmark, Vejle, Denmark., Lauridsen JT; Department of Economics, University of Southern Denmark, Odense, Denmark., Rasmussen LE; Department of Orthopaedic Surgery, Lillebaelt Hospital - Vejle, University Hospital of Southern Denmark, Vejle, Denmark., Mortensen WCP; Department of Anesthesiology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark., Jensen HI; Department of Anesthesiology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Vaegter HB; Pain Research Group, Department of Anesthesiology and Intensive Care Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Lambertsen KL; Department of Neurology, Odense University Hospital, Odense, Denmark.; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; BRIDGE, Brain Research - Inter Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Jazyk:	angličtina
Zdroj:	Bone & joint research [Bone Joint Res] 2024 Dec 06; Vol. 13 (12), pp. 741-749. Date of Electronic Publication: 2024 Dec 06.
DOI:	10.1302/2046-3758.1312.BJR-2024-0103.R1
Abstrakt:	Aims: Better prediction of outcome after total hip arthroplasty (THA) is warranted. Systemic inflammation and central neuroinflammation are possibly involved in progression of osteoarthritis and pain. We explored whether inflammatory biomarkers in blood and cerebrospinal fluid (CSF) were associated with clinical outcome, and baseline pain or disability, 12 months after THA. Methods: A total of 50 patients from the Danish Pain Research Biobank (DANPAIN-Biobank) between January and June 2018 were included. Postoperative outcome was assessed as change in Oxford Hip Score (OHS) from baseline to 12 months after THA, pain was assessed on a numerical rating scale, and disability using the Pain Disability Index. Multiple regression models for each clinical outcome were included for biomarkers in blood and CSF, respectively, including age, sex, BMI, and Kellgren-Lawrence score. Results: Change in OHS was associated with blood concentrations of tumour necrosis factor (TNF), interleukin-8 (IL-8), interleukin-6 receptor (IL-6R), glycoprotein 130 (gp130), and IL-1β (R 2 = 0.28, p = 0.006), but not with CSF biomarkers. Baseline pain was associated with blood concentrations of lymphotoxin alpha (LTα), TNFR1, TNFR2, and IL-6R (R 2 = 0.37, p < 0.001) and CSF concentrations of TNFR1, TNFR2, IL-6, IL-6R, and IL-1Ra (R 2 = 0.40, p = 0.001). Baseline disability was associated with blood concentrations of TNF, LTα, IL-8, IL-6, and IL-1α (R 2 = 0.53, p < 0.001) and CSF concentrations of gp130, TNF, and IL-1β (R 2 = 0.26, p = 0.002). Thus, preoperative systemic low-grade inflammation predicted 12-month postoperative outcome after THA, and was associated with preoperative pain and disability. Conclusion: This study highlights the importance of systemic inflammation in osteoarthritis, and presents a possible path for better patient selection for THA in the future. Preoperative central neuroinflammation was associated with preoperative pain and disability, but not change in OHS after THA. Competing Interests: C. Varnum received travel expenses from Stryker and L. E. Rasmussen received travel expenses and fees for participation in advisory board from Stryker, both through a company research grant to their department. (© 2024 Blichfeldt-Eckhardt et al.)
Databáze:	MEDLINE
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