Biological interaction of bioactive polymeric membranes in induced bone defects in rabbit tibias.

Autor: da Cunha O; Department of Veterinary Sciences, Federal University of Paraná, Curitiba, Palotina-PR, Brazil., Ferrigno CRA; Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN, United States of America., da Silveira SD; Graduate Program in Animal Science, Federal University of Paraná, Curitiba, Palotina-PR, Brazil., Pedron BG; Department of Anesthesiology, Teaching and Research Institute of Hospital Sírio-Libanês, São Paulo-SP, Brazil., Komorizono DT; Private Sector, São Paulo-SP, Brazil., Prado FCR; Department of Stomatology, University of São Paulo, São Paulo-SP, Brazil., Cabrera WIR; University of São Paulo, São Paulo-SP, Brazil., Corrêa L; Department of Stomatology, University of São Paulo, São Paulo-SP, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Dec 05; Vol. 19 (12), pp. e0313834. Date of Electronic Publication: 2024 Dec 05 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0313834
Abstrakt: The study aimed to evaluate bone repair using three osteoinductive polymers in bone defects created in rabbit tibias. Forty-eight adult rabbits were assessed at various time points: three, seven, fourteen, and thirty days. The groups included a control group (without biomaterial), M1 (Poly L Lactide co Polycaprolactone/Polyethylene Glycol), M2 (Poly L Lactide co Polycaprolactone/Polyethylene Glycol/β-Tricalcium Phosphate), and M3 (Poly L Lactide co Polycaprolactone/Polyethylene Glycol/nano hydroxyapatite). Histomorphometric analysis was conducted to evaluate new bone formation within and around the bone defect. At 14 (p<0.05) and 30 days (p<0.05), the callus area in the membrane groups, particularly in M3, was also significantly larger than in the control group, indicating the osteoinductive potential of these biomaterials. The callus consisted of both bone and cartilaginous matrix, suggesting a robust activation of endochondral ossification. The number of osteoclast was higher in the membrane groups, especially at 14 days in the M3 group, indicating increased bone remodeling activity. The membranes were not fully absorbed by 30 days, creating a space between the defect and the periosteum. In conclusion, all three membranes showed significant chondro and osteoinductive potential, with the membrane containing nano-hydroxyapatite demonstrating the most pronounced potential.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 da Cunha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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