Lack of correlation between asprosin serum levels and hyperphagic behavior in subjects with prader-Willi Syndrome.

Autor: Faienza MF; Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'A. Moro', Bari, Italy. mariafelicia.faienza@uniba.it., Chiarito M; Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'A. Moro', Bari, Italy., Aureli A; Endocrinology and Diabetology Unit, Pediatric University Department, Bambino Gesù Children Hospital, IRCCS, Rome, Italy., Buganza R; Pediatric Endocrinology, Department of Public Health and Pediatric Sciences, Regina Margherita Children Hospital, University of Torino, Torino, Italy., Corica D; Department of Human Pathology of Adulthood and Childhood 'G.Barresi', Unit of Pediatrics, University of Messina, Messina, Italy., Delvecchio M; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, L'Aquila, Italy., De Sanctis L; Pediatric Endocrinology, Department of Public Health and Pediatric Sciences, Regina Margherita Children Hospital, University of Torino, Torino, Italy., Fintini D; Endocrinology and Diabetology Unit, Pediatric University Department, Bambino Gesù Children Hospital, IRCCS, Rome, Italy., Grugni G; Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Verbania, Italy., Licenziati MR; Neuro-Endocrine Diseases and Obesity Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital, Naples, Italy., Madeo S; Department of Medical and Surgical Sciences for Mother, Children and Adults, Pediatric Unit, University of Modena and Reggio Emilia, Modena, Italy., Mozzillo E; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy., Rutigliano I; Pediatric Unit, IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo (FG), Italy., Valerio G; Department of Medical, Movement and Wellbeing Sciences, Parthenope University of Naples, Naples, Italy.
Jazyk: angličtina
Zdroj: Journal of endocrinological investigation [J Endocrinol Invest] 2024 Dec 05. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1007/s40618-024-02511-2
Abstrakt: Purpose: Individuals with Prader-Willi syndrome (PWS) exhibit hyperphagic behavior, the severity of which varies throughout life. The mechanisms underlying this behavior are still unknown. Asprosin is a new discovered adipokine involved in the regulation of food intake, glucose homeostasis and energy balance. In this study we assessed asprosin serum levels in a cohort of children, adolescents and adults with PWS with the aim to correlate them with hyperphagic behavior, body mass index (BMI) and metabolic parameters, and to evaluate age-related changes.
Methods: This cross-sectional study included 87 children and adolescents and 31 adults with PWS. Auxological data, fasting levels of glucose, insulin, total cholesterol, high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG) and asprosin were collected, and the homeostasis model assessment for insulin resistance (HOMA-IR) was determined. The 11-item Italian version of the Hyperphagia Questionnaire (HQ) was administered to the parents/caregivers of the patients to assess hyperphagia.
Results: Patients were analysed according to age (children < 10 years, adolescents between 10 and 17.9 years, adults ≥ 18 years) or BMI categories [normal weight (NW), overweight (OW), and obesity (OB)]. No significant correlations were found between asprosin levels and cardiometabolic risk factors in the whole cohort. Higher values of asprosin were found in adults compared with adolescents, as well as in the OB group compared to the NW group (p = 0.014). Hyperphagia total score and hyperphagic subdimensions were significantly lower in children compared to adults (p < 0.05). Similarly, hyperphagia total score and hyperphagic subdimensions were significantly lower in the NW group compared to the OB group. Asprosin levels were significantly higher in patients with deletion versus patients with uniparental disomy (p = 0.037). By logistic regression analysis, HQ total score and hyperphagic subdimensions were significantly associated with BMI-SDS independently of age, sex, and asprosin levels.
Conclusion: In conclusion, our data demonstrated higher asprosin levels in PWS individuals with OB compared to NW, while differences by age and sex were inconsistent. The lower levels of hyperphagia, BMI-SDS, and metabolic variables in children with PWS compared to adults underline that prevention of obesity should start very early in life and should be maintained over time.
Competing Interests: Declarations. Conflict of interest: The authors declare no conflict of interest. Informed Consent: Written consent was obtained from all participants and their parents, after having informed them of the purpose of the study.
(© 2024. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).)
Databáze: MEDLINE
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