Being born extremely preterm with low-grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhood.

Autor: Broström L; Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Stockholm, Sweden., de Gamarra-Oca LF; Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain., Kvanta H; Neonatal Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Örtqvist M; Neonatal Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Functional Area Occupational Therapy & Physiotherapy, Allied Health Professionals Function, Karolinska University Hospital, Stockholm, Sweden., Padilla N; Neonatal Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Ådén U; Neonatal Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Neonatal Unit Karolinska University Hospital, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Dec 05. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1111/apa.17517
Abstrakt: Aim: Our aim was to investigate the impact that low-grade intraventricular haemorrhage (IVH) had on neonatal morbidities, brain volumes and neurodevelopmental outcomes in children born extremely preterm (EPT) and compare them with children born EPT without low-grade IVH.
Methods: This prospective cohort study was carried out in Stockholm, Sweden. It focused on 103 children born EPT from 2004 to 2007, at less than 27 weeks of gestation, without major brain injuries. The group with low-grade IVH, defined as grades I-II, were compared with children born EPT without IVH. Around half (45%) underwent MRI scans at 10 years of age and 55% had neurodevelopmental assessments at 12 years.
Results: The low-grade IVH group was sicker during the neonatal period than the children born EPT without IVH. They had lower gestational ages at birth, more days on mechanical ventilation, a higher incidence of necrotising enterocolitis and were more likely to need surgical ligation of patent ductus arteriosus. However, they did not have significantly smaller brain volumes at 10 years of age or worse neurodevelopmental outcomes at 12 years of age.
Conclusion: Brain volumes or neurodevelopment were not affected in children born EPT with low-grade IVH, compared to children born EPT without IVH.
(© 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
Externí odkaz: