Capillary-assisted flat-field formation: a platform for advancing nanoparticle tracking analysis in an integrated on-chip optofluidic environment.

Autor:	Gui F; The Department of Fiber Photonics, Leibniz Institute of Photonic Technology, Albert-Einstein-Street 9, 07745 Jena, Germany., Foerster R; The Department of Fiber Photonics, Leibniz Institute of Photonic Technology, Albert-Einstein-Street 9, 07745 Jena, Germany., Wieduwilt T; The Department of Fiber Photonics, Leibniz Institute of Photonic Technology, Albert-Einstein-Street 9, 07745 Jena, Germany., Zeisberger M; The Department of Fiber Photonics, Leibniz Institute of Photonic Technology, Albert-Einstein-Street 9, 07745 Jena, Germany., Kim J; The Department of Fiber Photonics, Leibniz Institute of Photonic Technology, Albert-Einstein-Street 9, 07745 Jena, Germany., Schmidt MA; The Department of Fiber Photonics, Leibniz Institute of Photonic Technology, Albert-Einstein-Street 9, 07745 Jena, Germany.; Abbe Center of Photonics and Faculty of Physics, Friedrich-Schiller-University Jena, Max-Wien-Platz 1, 07743 Jena, Germany.; Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Fraunhoferstr. 6, 07743 Jena, Germany.
Jazyk:	angličtina
Zdroj:	Nanophotonics (Berlin, Germany) [Nanophotonics] 2024 May 20; Vol. 13 (17), pp. 3135-3145. Date of Electronic Publication: 2024 May 20 (Print Publication: 2024).
DOI:	10.1515/nanoph-2024-0139
Abstrakt:	Here, we present the concept of flat-field capillary-assisted nanoparticle tracking analysis for the characterization of fast diffusing nano-objects. By combining diffusion confinement and spatially invariant illumination, i.e., flat-fields, within a fiber-interfaced on-chip environment, ultra-long trajectories of fast diffusing objects within large microchannels have been measured via diffraction-limited imaging. Our study discusses the design procedure, explains potential limitations, and experimentally confirms flat-field formation by tracking gold nanospheres. The presented concept enables generating flat-fields in a novel on-chip optofluidic platform for the characterization of individual nano-objects for fundamental light/matter investigations or applications in bioanalytics and nanoscale material science. Competing Interests: Conflict of interest: Authors state no conflict of interest. (© 2024 the author(s), published by De Gruyter, Berlin/Boston.)
Databáze:	MEDLINE
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