A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.

Autor:	Murphy AL; College of Pharmacy, Dalhousie University, Halifax, NS, Canada.; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.; School of Nursing, Dalhousie University, Halifax, NS, Canada., Sawires K; College of Pharmacy, Dalhousie University, Halifax, NS, Canada., Peltekian SM; Pharmacy Department, Nova Scotia Health Authority, Halifax, NS, Canada., Helwig M; WK Kellogg Health Sciences Library, Dalhousie University, Halifax, NS, Canada., Macdonald M; School of Nursing, Dalhousie University, Halifax, NS, Canada., Martin-Misener R; School of Nursing, Dalhousie University, Halifax, NS, Canada., Saini B; School of Pharmacy, University of Sydney, Sydney, NSW, Australia., Neyedli H; School of Health and Human Performance, Dalhousie University, Halifax, NS, Canada., Giacomantonio C; Sociology and Social Anthropology, Dalhousie University, Halifax, NS, Canada., Gardner DM; College of Pharmacy, Dalhousie University, Halifax, NS, Canada.; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Jazyk:	angličtina
Zdroj:	Exploratory research in clinical and social pharmacy [Explor Res Clin Soc Pharm] 2024 Nov 09; Vol. 16, pp. 100538. Date of Electronic Publication: 2024 Nov 09 (Print Publication: 2024).
DOI:	10.1016/j.rcsop.2024.100538
Abstrakt:	Background: Benzodiazepines and Z -drugs (e.g., zopiclone, zolpidem) (benzodiazepine receptor agonists or BZRAs), are prescribed for anxiety and insomnia disorders. However, they are not indicated as first line therapies for long-term management due to harms and efficacy limitations. BZRAs have also been associated with traffic accident risks. Patients taking BZRAs are told to consult with health care providers regarding motor vehicle operation safety. However, advice on driving is variable. The objective of this scoping review is to identify, map, and characterize the evidence for assessments that measure driving performance in people taking BZRAs. Methods: Embase (Elsevier), MEDLINE (Ovid), and PsycINFO (EBSCO) were searched. Covidence was used for screening. Each stage of screening included two independent reviewers. A REDCap database was used for data extraction by two independent reviewers. Results were tabulated and summarised as a narrative. Results: Driving performance was assessed with 20 unique BZRAs across 183 studies ( n  = 92 experimental; n  = 91 observational) in 178 publications. Zopiclone was the most studied. In experimental studies, the Standard Deviation of Lateral Position (SDLP) was used most often ( n  = 54, 62 %) and many studies ( n  = 35, 38 %) were conducted in the Netherlands. For observational studies, biological detection (e.g., urine, blood) ( n  = 73, 80 %) followed by prescription drug/dispensing records ( n  = 17, 19 %) were the most common impairment measures and Norway ( n  = 20) is where most studies took place. In experimental studies, most ( n  = 89, 97 %) were conducted using only one driving setting. Simulated driving in a car ( n  = 36) and road driving in traffic (n = 36) were common as compared to nontraffic driving course (n = 8) and simulated driving ( n  = 9). In experimental studies, seventy-eight of the 92 studies (85 %) had at least one measure that identified impairment. Conclusions: BZRA effects on motor vehicle driving performance have been studied using heterogenous protocols with multiple measures and settings, ranging from simulation to authentic traffic situations in experimental studies to biological detection and dispensing records in observational studies. Many BZRAs have been studied but study representation does not match prescribing pattern prevalence. The interpretation and contextualization of results for clinical practice is challenging due to the complexity (i.e., protocols, measures, settings). Future work in this area should work to improve knowledge translation of results so information is more readily accessible and applicable to health care providers and patients. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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