Differences in total and differential white blood cell counts and in inflammatory parameters between psychiatric inpatients with and without recent consumption of cannabinoids, opioids, or cocaine: A retrospective single-center study.
| Autor: | Llorca-Bofí V; Department of Psychiatry, Hospital Universitari Santa Maria, Lleida, Spain.; Department of Medicine, University of Barcelona, Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain.; Department of Medicine and Surgery, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida (IRBLleida), Spain., Mur M; Department of Psychiatry, Hospital Universitari Santa Maria, Lleida, Spain.; Department of Medicine and Surgery, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida (IRBLleida), Spain., Font M; Laboratory Department, Arnau de Vilanova University Hospital, Lleida, Spain., Palacios-Garrán R; Department of Psychiatry, Hospital Universitari Santa Maria, Lleida, Spain.; Mental Health Unit, Hospital Universitario Jerez de la Frontera, University of Cádiz, Cádiz, Spain., Sellart M; Department of Psychiatry, Hospital Universitari Santa Maria, Lleida, Spain., Del Agua-Martínez E; Department of Psychiatry, Hospital Universitari Santa Maria, Lleida, Spain., Bioque M; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Medicine, University of Barcelona, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain., Arteaga-Henríquez G; Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.; NCRR-National Center for Register-based Research, Aahrus University, Aahrus, Denmark. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Brain, behavior, & immunity - health [Brain Behav Immun Health] 2024 Nov 06; Vol. 42, pp. 100898. Date of Electronic Publication: 2024 Nov 06 (Print Publication: 2024). |
| DOI: | 10.1016/j.bbih.2024.100898 |
| Abstrakt: | Several drugs of abuse may exert their action by modulating the immune system. Despite this, individuals using substances of abuse are often excluded from immunopsychiatry studies. We conducted a retrospective, single-center study to examine differences in circulating immune/inflammatory parameters (i.e., total and differential white blood cell (WBC) counts, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte (MLR) ratio, platelet-to-lymphocyte ratio, and C-reactive protein) between psychiatric inpatients with a positive urine test to cannabinoids, opioids, or cocaine, and those with negative toxicology. A total of 927 inpatients were included. Patients with positive toxicology (n = 208) had significantly higher WBC counts ( P < 0.001, η 2 p = 0.02), as well as increased neutrophils ( P = 0.002, η 2 p = 0.01), monocytes ( P < 0.001, η 2 p = 0.02), lymphocytes ( P < 0.001, η 2 p = 0.02), and eosinophils ( P = 0.01, η 2 p = 0.01) compared to those with negative toxicology (n = 719). The increase in neutrophil counts was particularly evident in patients who tested positive for cannabinoids (n = 168; P < 0.001, η 2 p = 0.02). In contrast, eosinophil counts were particularly increased in the cocaine-positive subgroup (n = 27; P = 0.004, η 2 p = 0.01). Patients with a positive urine test to opioids (n = 13) were characterized by a significantly lower MLR ( P = 0.03, η 2 p = 0.005). The type of psychiatric diagnosis moderated the differences in neutrophil counts between patients with a positive and negative toxicology to cannabinoids. Notably, significantly higher neutrophil counts were found only in patients diagnosed with a psychotic disorder ( P < 0.001, η 2 p = 0.03). Taken together, our findings suggest that drugs of abuse may differently impact the immune/inflammatory response system in individuals diagnosed with psychiatric conditions. Specifically, recent cannabinoids use may be associated with an acute activation of the inflammatory response system, particularly in individuals with a psychotic disorder, while cocaine and opioid use may be associated with eosinophilia and a decrease in the MLR, respectively, regardless of the primary psychiatric diagnosis. Competing Interests: VL-B reported receiving financial support for continuing medical education from 10.13039/501100004231Adamed, 10.13039/501100024679Advanz Pharma, 10.13039/501100006546Angelini, 10.13039/501100012408Casen Recordati, Exeltis, Janssen, 10.13039/501100013327Lundbeck, 10.13039/100014593Neurocrine Biosciences and Rovi outside the submitted work. GA-H reported receiving personal fees from Janssen outside the submitted work. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|