Metastasizing dysgerminoma in an inland bearded dragon (Pogona vitticeps).

Autor: Schmidt-Ukaj S; Service for Birds and Reptiles, Clinical Centre for Small Animals, University of Veterinary Medicine, Vienna, Austria. silvana.schmidt-ukaj@vetmeduni.ac.at., Brunthaler R; Institute for Pathology, University of Veterinary Medicine, Vienna, Austria., Gumpenberger M; Clinical Unit for Diagnostic Imaging, University of Veterinary Medicine, Vienna, Austria.
Jazyk: angličtina
Zdroj: BMC veterinary research [BMC Vet Res] 2024 Dec 05; Vol. 20 (1), pp. 552. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1186/s12917-024-04368-2
Abstrakt: Background: Malignant dysgerminomas are infrequently reported ovarian neoplasms in animals, especially in exotic pets (non-traditional companion animals [NTCAs]). In the few published case reports on reptilian species, examples are primarily postmortem without antemortem (clinical) assessment.
Patient Presentation: An adult, 13-year-old, spayed female inland bearded dragon (Pogona vitticeps) presented with lethargy, a right-sided head tilt, unilateral exophthalmos and ventrotemporal strabismus on the right eye. On examination, a palpable mass (approximately 3.5 cm in diameter) was detected within the mid coelomic cavity. Computed tomography revealed a retrobulbar swelling and lytic bone lesions affecting the right frontal bone and several vertebrae (T11, T13, and T14). Multiple nodules of soft tissue opacity were also detected within the lungs, liver, and coelomic fat bodies. Haematology revealed leukocytosis with heterophilia and toxic granulation of heterophils. On the basis of these results, differential diagnoses included disseminated abscesses, granulomas (e.g., due to mycobacteriosis) and neoplasms. The lizard was subsequently euthanized due to end-stage disease and a poor prognosis. Postmortem gross examination and histopathology revealed a primary ovarian dysgerminoma with evidence of widespread metastasis as well as localized tissue destruction affecting the right retrobulbar space and frontal bone, the spinal column, the lungs, the liver, and both coelomic fat bodies.
Conclusions: This report describes a case of malignant dysgerminoma with widespread intraosseous and visceral metastases in a captive inland bearded dragon (Pogona vitticeps).
Competing Interests: Declarations. Consent for publication: Written informed consent was obtained from the owner for the participation of his/her animal in this case study. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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