Cranial ultrasonographic findings in newborns exposed to SARS-CoV-2: a single-centre cross-sectional analysis.

Autor: Scalia B; Unit of Neonatology, University Hospital Policlinico G. Rodolico- San Marco, P.O. San Marco, Viale Carlo Azeglio Ciampi, Catania, 95121, Italy. b.scalia@hotmail.it., Saporito MAN; Unit of Neonatology, University Hospital Policlinico G. Rodolico- San Marco, P.O. San Marco, Viale Carlo Azeglio Ciampi, Catania, 95121, Italy., Mauceri L; Unit of Neonatology, University Hospital Policlinico G. Rodolico- San Marco, P.O. San Marco, Viale Carlo Azeglio Ciampi, Catania, 95121, Italy., Saporito AV; Unit of Neonatology, University Hospital Policlinico G. Rodolico - San Marco, P.O. G. Rodolico, Via S. Sofia 78, Catania, 95121, Italy., Privitera GF; Department of Clinical and Experimental Medicine, Bioinformatics Unit, University of Catania, Catania, Italy., Ruggieri M; Unit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, A.O.U., P.O. G. Rodolico, Via S. Sofia 78, Catania, Italy., Falsaperla R; Department of Medical Science-Pediatrics, University of Ferrara, Ferrara, Italy.
Jazyk: angličtina
Zdroj: Italian journal of pediatrics [Ital J Pediatr] 2024 Dec 05; Vol. 50 (1), pp. 257. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1186/s13052-024-01826-3
Abstrakt: Background: SARS-CoV-2's potential consequences on the developing brain are still unknown. The aim of this study was to describe cranial ultrasonographic (cUS) findings in a population of newborns exposed to SARS-CoV-2 born at San Marco Hospital in Catania.
Methods: Two cohort of newborns, one exposed to SARS-CoV-2 both during gestation and at birth and one unexposed, were enrolled in this cross-sectional study conducted according to the STROBE guidelines (Strenghtening the Reporting of Observational Studies in Epidemiology) and underwent cUS. We performed a statistical analysis using the Fisher's exact test to assess whether significant differences among the two groups existed.
Results: we enrolled 139 exposed newborns (62 females, 77 males with median gestational age 38.4 ± 1.9 W and median weight at birth 3142.8 ± 594.4 g) and 139 unexposed newborns (60 females, 79 males with median gestational age 38,9 ± 1.3 W and median weight at birth 3230 ± 336 g). cUS abnormalities were found in 32 exposed patients (23%) and in 23 (16.5%) unexposed patients. A statistically significant difference was found in the incidence of minor intracranial abnormalities (p 0.036) between exposed and unexposed patients and between newborns exposed during pregnancy and unexposed patients (p 0.016).
Conclusions: in our experience, the incidence of minor intracranial abnormalities was higher in SARS-COV-2-exposed newborns. Our results must be taken with caution and need further confirmation in larger studies but suggest to consider performing cUS at birth in newborns exposed to SARS-CoV-2 in research contexts.
Competing Interests: Declarations. Ethics approvals and consent to participate: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the Helsinki Declaration (as revised in 2013). The study was approved by the ethical committee of the Medical Faculty of the University of Catania (IRB n. 780). Written informed consent was obtained from the patient’s parents for publication of this case report and accompanying images. A copy of the written consent is available for review by the editorial office of this journal. Consent for publication: Written informed consent was obtained from the patient’s parents for publication of this case series and the accompanying images. Competing interests: Raffaele Falsaperla has an editorial role in this journal. Other authors have no competing interests to declare.
(© 2024. The Author(s).)
Databáze: MEDLINE
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