Dynamics of the blood plasma proteome during hyperacute HIV-1 infection.

Autor: Nazziwa J; Department of Translational Medicine, Lund University, Lund, Sweden.; Lund University Virus Centre, Lund University, Lund, Sweden., Freyhult E; National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Hong MG; National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Johansson E; Department of Translational Medicine, Lund University, Lund, Sweden.; Lund University Virus Centre, Lund University, Lund, Sweden., Årman F; BioMS-Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden., Hare J; IAVI Human Immunology Laboratory, Imperial College, London, UK.; IAVI, New York, NY, USA.; IAVI, Nairobi, Kenya., Gounder K; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK., Rezeli M; BioMS-Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden.; Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden., Mohanty T; Division of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden., Kjellström S; BioMS-Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden., Kamali A; IAVI, New York, NY, USA.; IAVI, Nairobi, Kenya., Karita E; Center for Family Health Research, Kigali, Rwanda., Kilembe W; Center for Family Health Research, Lusaka, Zambia., Price MA; IAVI, New York, NY, USA.; IAVI, Nairobi, Kenya.; UCSF Department of Epidemiology and Biostatistics, San Francisco, CA, USA., Kaleebu P; Uganda Research Unit, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine, Entebbe, Uganda., Allen S; Center for Family Health Research, Kigali, Rwanda.; Center for Family Health Research, Lusaka, Zambia.; Department of Pathology & Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, USA., Hunter E; Center for Family Health Research, Kigali, Rwanda.; Center for Family Health Research, Lusaka, Zambia.; Department of Pathology & Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, USA., Ndung'u T; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Gilmour J; Department of Infectious Diseases, Infection and Immunity, Faculty of Medicine, Imperial College, London, UK., Rowland-Jones SL; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Sanders E; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; The Aurum Institute, Johannesburg, South Africa., Hassan AS; Department of Translational Medicine, Lund University, Lund, Sweden.; Lund University Virus Centre, Lund University, Lund, Sweden.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Institute for Human Development, Aga Khan University, Nairobi, Kenya., Esbjörnsson J; Department of Translational Medicine, Lund University, Lund, Sweden. joakim.esbjornsson@med.lu.se.; Lund University Virus Centre, Lund University, Lund, Sweden. joakim.esbjornsson@med.lu.se.; Nuffield Department of Medicine, University of Oxford, Oxford, UK. joakim.esbjornsson@med.lu.se.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Dec 05; Vol. 15 (1), pp. 10593. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1038/s41467-024-54848-0
Abstrakt: The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levels with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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