Self-Reinforcing Ionogel Bioadhesive Interface for Robust Integration and Monitoring of Bioelectronic Devices with Hard Tissues.

Autor: Jiang C; Stomatological College of Nanjing Medical University, Jiangsu Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Department of General Dentistry Affiliated Hospital of Stomatology Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, 210029, China., Fu J; School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai, 201210, China., Zhang H; School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai, 201210, China., Hua Y; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, No.639, Zhizaoju Road, Shanghai, 200011, China., Cao L; School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai, 201210, China., Ren J; School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai, 201210, China., Zhou M; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, No.639, Zhizaoju Road, Shanghai, 200011, China., Jiang F; Stomatological College of Nanjing Medical University, Jiangsu Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Department of General Dentistry Affiliated Hospital of Stomatology Nanjing Medical University, No. 140, Han Zhong Road, Nanjing, 210029, China., Jiang X; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, No.639, Zhizaoju Road, Shanghai, 200011, China., Ling S; School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai, 201210, China.; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Dec 05, pp. e2413028. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1002/adma.202413028
Abstrakt: Integrating bioelectronic devices with hard tissues, such as bones and teeth, is essential for advancing diagnostic and therapeutic technologies. However, stable and durable adhesion in dynamic, moist environments remains challenging. Traditional bioadhesives often fail to maintain strong bonds, especially when interfacing with metal electrodes and hard tissues. This study introduces a self-reinforcing ionogel bioadhesive interface (IGBI) combining silk fibroin and calcium ions, designed to provide robust and conductive integration of bioelectronic devices with hard tissues. The IGBI exhibits strong adhesion (up to 186 J m -2 ) and undergoes mechanical self-reinforcement through a structural transition in silk fibroin under physiological conditions. In vivo experiments demonstrate the IGBI's effectiveness in repairing bone defects and reimplanting teeth, with the added capability of wireless, real-time monitoring of bone healing. This approach allows for continuous tracking of tissue regeneration without a second invasive surgery for device removal. The IGBI represents a significant advancement in bioelectronic integration, offering a durable and versatile solution for challenging environments. Such unique self-reinforcing properties make the IGBI a promising material for biomedical applications where traditional adhesives are insufficient.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: