The association of prenatal volatile organic compounds exposure and newborn anthropometrics: A cross-sectional study.

Autor: Michael T; Department of Epidemiology, Biostatistics, and Community Health Sciences, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev Beer-Sheva, Israel., Solt I; Department of Obstetrics and Gynecology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. Electronic address: i_solt@rambam.health.gov.il., Daniel S; Clalit Health Services, Southern District, Beer-Sheva, Israel., Levy A; Department of Epidemiology, Biostatistics, and Community Health Sciences, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev Beer-Sheva, Israel; Environment and Health Epidemiology Research Center, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Hochwald O; Neonatal Intensive Care Unit, Rambam Health Care Campus, and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel., Borenstein-Levin L; Neonatal Intensive Care Unit, Rambam Health Care Campus, and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel., Hazan A; Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, Israel., Berkovitch M; Clinical Pharmacology and Toxicology Unit, Shamir Medical Center, Zerifin, The Andy Lebach Chair of Clinical Pharmacology and Toxicology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Brik A; Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, Israel., Rabin AM; Department of Obstetrics and Gynecology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel., Betser M; Delivery Rooms and Maternity Ward, Shamir (Assaf Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, Israel., Moskovich M; Delivery Rooms and Maternity Ward, Shamir (Assaf Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, Israel., Livne A; Neonatal Intensive Care Unit, Shamir (Assaf Harofeh) Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel., Keidar R; Neonatal Intensive Care Unit, Shamir (Assaf Harofeh) Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel., Schwartsburd F; National Residue Control Laboratory, Kimron Veterinary Institute, Veterinary Services, Ministry of Agriculture and Rural Development, Beit Dagan, Israel., Weiner Z; Department of Obstetrics and Gynecology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel., Kohn E; Clinical Pharmacology and Toxicology Unit, Pediatric Division, Shamir (Assaf Harofeh) Medical Center, and Sackler School of Medicine, Tel-Aviv University, Israel.
Jazyk: angličtina
Zdroj: International journal of hygiene and environmental health [Int J Hyg Environ Health] 2024 Dec 03; Vol. 264, pp. 114493. Date of Electronic Publication: 2024 Dec 03.
DOI: 10.1016/j.ijheh.2024.114493
Abstrakt: Background: Several studies have associated prenatal exposure to volatile organic compounds (VOCs) with adverse health outcomes among newborns. However, little is known about the associations of VOCs at relatively low concentrations with newborn outcomes. Hence, this study aimed to investigate the potential associations between prenatal exposure to VOCs and VOC mixtures with newborn anthropometric measures.
Methods: In this cross-sectional study, 883 mother-term infant pairs who lived in urban areas in Israel and were admitted to the delivery rooms of two major hospitals between 2016 and 2020 were recruited. Associations between VOC metabolites detected in maternal urine samples on the day of delivery with weight, length, and head circumference at birth were estimated using single-exposure linear models and weighted quantile sum (WQS) approach.
Results: Toluene, ethylbenzene/styrene, and xylene metabolites were detected in most samples at levels comparable to OECD populations. In male newborns, higher levels of phenylglyoxylic acid (PGA), a metabolite of ethylbenzene/styrene, were associated with lower birth weight (β = -0.08, 95% CI: 0.14, -0.01; P = 0.03). WQS models suggested PGA as the most prominent contributor to this association.
Conclusion: This study suggests that moderate exposure to ethylbenzene/styrene may be associated with reduced birth weight in male newborns. The sex-specific finding requires further research for the potential endocrine-disrupting mechanisms of these compounds. While the effect size was small, these results highlight the need to better understand the associations of frequent VOC exposures in levels similar to those common in OECD countries with fetal and child development.
Competing Interests: Competing interests The authors declare that they have no competing interests.
(Copyright © 2024. Published by Elsevier GmbH.)
Databáze: MEDLINE
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