Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes.

Autor: Tikhe CV; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA., Issiaka S; Institut de Recherche en Sciences de la Santé (IRSS) Direction Régionale de l'Ouest, Bobo-Dioulasso, BP 545, Burkina Faso.; Université Joseph Ki-Zerbo, Ouagadougou, 03 BP 7021, Burkina Faso.; Institut National de Santé Publique (INSP)/Centre Muraz, Bobo Dioulasso, Burkina Faso., Dong Y; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA., Kefi M; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA., Tavadia M; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA., Bilgo E; Institut de Recherche en Sciences de la Santé (IRSS) Direction Régionale de l'Ouest, Bobo-Dioulasso, BP 545, Burkina Faso.; Institut National de Santé Publique (INSP)/Centre Muraz, Bobo Dioulasso, Burkina Faso., Corder RM; School of Public Health, University of California Berkley, 2121 Berkeley Way #5328, Berkeley, CA 94720, USA., Marshall J; School of Public Health, University of California Berkley, 2121 Berkeley Way #5328, Berkeley, CA 94720, USA., Diabate A; Institut de Recherche en Sciences de la Santé (IRSS) Direction Régionale de l'Ouest, Bobo-Dioulasso, BP 545, Burkina Faso.; Institut National de Santé Publique (INSP)/Centre Muraz, Bobo Dioulasso, Burkina Faso., Dimopoulos G; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Dec 06; Vol. 10 (49), pp. eads3658. Date of Electronic Publication: 2024 Dec 04.
DOI: 10.1126/sciadv.ads3658
Abstrakt: Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting Anophelines has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium Chromobacterium sp. Panama ( Csp_P ) kills insecticide-resistant Anopheles mosquitoes, regardless of their resistance mechanisms. In addition, sublethal dose of Csp_P acts as a synergist to now used chemical insecticides across multiple classes. Moreover, Csp_P reduces host-seeking behavior and malaria parasite infection in vector mosquitoes in ways that further decrease transmission. Mosquito glutathione S -transferases are essential for Csp_P 's mosquito-killing mechanism. Enclosed field trials in Burkina Faso, conducted in diverse ecological settings and supported by a mathematical model, have now demonstrated its potential for malaria control in settings with widespread insecticide resistance.
Databáze: MEDLINE
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