Clinical, thermographic, and tensiometric evaluation of rat cutaneous wounds treated with collagen gel associated with F18 bioactive glass.

Autor:	Silva BMD; Universidade Estadual Paulista - School of Veterinary Medicine and Animal Science - Postgraduate Program in Animal Biotechnology - Botucatu (SP) - Brazil., Santos IFCD; Universidade Federal de Rondônia - Rolim de Moura (RO) - Brazil.; Universidade Estadual Paulista - School of Veterinary Medicine and Animal Science - Botucatu (SP) - Brazil., Mancuso P; Universidade Estadual Paulista - School of Veterinary Medicine and Animal Science - Botucatu (SP) - Brazil., Pereira LAF; Universidade Estadual Paulista - School of Veterinary Medicine and Animal Science - Botucatu (SP) - Brazil., Moroz I; Universidade Estadual Paulista - School of Agronomic Sciences - Department of Bioprocesses and Biotechnology - Botucatu (SP) - Brazil., Gallina MF; Universidade Estadual Paulista - School of Veterinary Medicine and Animal Science - Postgraduate Program in Animal Biotechnology - Botucatu (SP) - Brazil., Tsunemi MH; Universidade Estadual Paulista - Institute of Biosciences of Botucatu - Department of Biostatistics - Botucatu (SP) - Brazil., Souza MT; Vetra Pesquisa e Desenvolvimento de Produtos Cerâmicos de Alta Tecnologia - Ribeirão Preto (SP) - Brazil., Pellizzon CH; Universidade Estadual Paulista - Institute of Biosciences of Botucatu - Department of Structural and Functional Biology - Botucatu (SP) - Brazil., Silva Júnior JIS; Universidade Estadual Paulista - School of Veterinary Medicine and Animal Science - Postgraduate Program in Animal Biotechnology - Botucatu (SP) - Brazil., Brandão CVS; Universidade Estadual Paulista - School of Veterinary Medicine and Animal Science - Department of Veterinary Surgery and Animal Reproduction - Botucatu (SP) - Brazil., Alves LAG; Universidade Federal de Rondônia - Rolim de Moura (RO) - Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2024 Nov 29; Vol. 39, pp. e399424. Date of Electronic Publication: 2024 Nov 29 (Print Publication: 2024).
DOI:	10.1590/acb399424
Abstrakt:	Purpose: To evaluate the association of collagen gel with F18 bioactive glass (BG) in the healing of non-contaminated cutaneous wounds induced in healthy Wistar rats. Methods: One hundred twelve adult and healthy Wistar rats were randomly divided into four groups (n = 28): saline solution (0.9%); healing ointment based on allantoin and zinc oxide; collagen gel; and association of F18 BG powder and collagen gel. All the rats underwent the creation of a 3-cm diameter wound in their dorsal region. Macroscopic, thermographic, and tensiometric evaluations of the wound were performed. Results: The presence of granulation tissue varied significantly in and between the groups. The surface temperature assessed through thermography of wounds treated with saline solution (0.9%) increased significantly over time and between the groups. No difference was identified regarding tensiometry. Conclusions: Collagen gel associated with F18 BG induced beneficial healing effects on non-contaminated cutaneous wounds in Wistar rats, which included the induction of increased blood perfusion as assessed through thermography.
Databáze:	MEDLINE
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