Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy.

Autor:	Abdolmohammadi B; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Tuz-Zahra F; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Uretsky M; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Nicks R; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts.; VA Bedford Healthcare System, US Department of Veteran Affairs, Bedford, Massachusetts., Mosaheb S; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Labonte J; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Yhang E; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Durape S; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Martin B; Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, Massachusetts., Palmisano J; Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, Massachusetts., Nowinski C; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Concussion Legacy Foundation, Boston, Massachusetts., Cherry JD; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts.; Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Alvarez VE; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts.; VA Bedford Healthcare System, US Department of Veteran Affairs, Bedford, Massachusetts.; Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Huber BR; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts.; VA Bedford Healthcare System, US Department of Veteran Affairs, Bedford, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Dams-O'Connor K; Department of Rehabilitation and Human Performance, Brain Injury Research Center, Icahn School of Medicine at Mount Sinai, New York, New York.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York., Crary J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Dwyer B; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Braintree Rehabilitation Hospital, Braintree, Massachusetts., Daneshvar DH; Department of Rehabilitation Medicine, Harvard Medical School, Boston, Massachusetts., Goldstein LE; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Biomedical Engineering, Boston University College of Engineering, Boston, Massachusetts.; Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Radiology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Au R; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts., Katz DI; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Braintree Rehabilitation Hospital, Braintree, Massachusetts., Kowall NW; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Cantu RC; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurosurgery, Emerson Hospital, Concord, Massachusetts.; Department of Neurosurgery, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Stern RA; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.; Department of Neurosurgery, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Alosco ML; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Stein TD; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts.; VA Bedford Healthcare System, US Department of Veteran Affairs, Bedford, Massachusetts.; Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Tripodis Y; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.; Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., McKee AC; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; VA Boston Healthcare System, US Department of Veteran Affairs, Boston, Massachusetts.; VA Bedford Healthcare System, US Department of Veteran Affairs, Bedford, Massachusetts.; Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts., Mez J; Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Boston University CTE Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Framingham Heart Study, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Jazyk:	angličtina
Zdroj:	JAMA network open [JAMA Netw Open] 2024 Dec 02; Vol. 7 (12), pp. e2449106. Date of Electronic Publication: 2024 Dec 02.
DOI:	10.1001/jamanetworkopen.2024.49106
Abstrakt:	Importance: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHIs). Prior research suggests a dose-response association between American football play duration and CTE risk and severity, but this association has not been studied for ice hockey. Objective: To investigate associations of duration of ice hockey play with CTE diagnosis and severity, functional status, and dementia. Design, Setting, and Participants: This cross-sectional study was conducted among male brain donors in the Understanding Neurological Injury and Traumatic Encephalopathy and Framingham Heart Study Brain Banks whose primary RHI exposure was from ice hockey. Donors died, brains were donated, and data were collected between July 1997 and January 2023. Data analysis was conducted from January 2023 to May 2024. Exposures: Ice hockey years played as an RHI proxy. Main Outcomes and Measures: CTE neuropathological diagnosis, cumulative phosphorylated tau (ptau) burden across 11 brain regions commonly affected in CTE, informant-reported Functional Activities Questionnaire (FAQ) score at death, and consensus dementia diagnosis were assessed. Results: Among 77 male donors (median [IQR] age, 51 [33-73] years), 42 individuals (54.5%) had CTE, including 27 of 28 professional players (96.4%). CTE was found in 5 of 26 donors (19.2%) who played fewer than 13 years, 14 of 27 donors (51.9%) who played 13 to 23 years, and 23 of 24 donors (95.8%) who played more than 23 years of hockey. Increased years played was associated with increased odds for CTE (odds ratio [OR] per 1-year increase, 1.34; 95% CI, 1.15-1.55; P < .001) and with increased ptau burden (SD increase per 1-year increase = 0.037; 95% CI, 0.017-0.057; P < .001) after adjusting for age at death, other contact sports played, age of first hockey exposure, concussion count, and hockey position. Simulation demonstrated that years played remained associated with CTE when years played and CTE were both associated with brain bank selection across widely ranging scenarios (median [full range] OR across all simulations, 1.34 [1.29-1.40]). Increased ptau burden was associated with FAQ score (βstandardized = 0.045; 95% CI, 0.021-0.070; P < .001) and dementia (OR per SD increase, 1.12; 95% CI, 1.01-1.26; P = .04) after adjusting for age at death, other contact sports played, hockey years played, enforcer status, age of first hockey exposure, concussion count, and hockey position. Conclusions and Relevance: In this study of male former ice hockey players, a dose-response association was observed between hockey years played and risk and severity of CTE. Simulation suggested that brain bank selection may not bias the magnitude of outcomes in the association.
Databáze:	MEDLINE
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