Relationship Between Whole Blood Iron Levels and Lipid Profile Parameters in the General Population: Findings from Routine Physical Examination Report.

Autor: Pan RJ; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Luo Z; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., You YS; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Wang JD; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Chen YQ; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Zhou RR; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Chen SZ; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Wang LM; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Zhao JX; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China., Su HQ; Taizhou Jiaojiang District Xiachen Street Community Health Service Centre, Xiachen Street Jiaojiang, 318000, Taizhou, Zhejiang, China., Wang CL; Taizhou Jiaojiang District Xiachen Street Community Health Service Centre, Xiachen Street Jiaojiang, 318000, Taizhou, Zhejiang, China., Zhang LF; Taizhou Jiaojiang District Xiachen Street Community Health Service Centre, Xiachen Street Jiaojiang, 318000, Taizhou, Zhejiang, China., Peng FL; Taizhou Jiaojiang District Xiachen Street Community Health Service Centre, Xiachen Street Jiaojiang, 318000, Taizhou, Zhejiang, China., Meneses JJ; Institute of Graduate Professional Studies, Tapuac District, Lyceum-Northwestern University, 2400, Dagupan City, Philippines., Wang XH; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China. Wxh515wwj@163.com., He LP; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China. lianpinghe@tzc.edu.cn., Wang T; School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China. wangtingyaoli@foxmail.com.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Dec 04. Date of Electronic Publication: 2024 Dec 04.
DOI: 10.1007/s12011-024-04459-z
Abstrakt: Dyslipidemia is related to the occurrence and development of many diseases and is a common problem among the general population. A significant link has been identified between dyslipidemia and ferroptosis. Lipid profile parameters are important indicators of dyslipidemia. Iron is the main cause of ferroptosis. However, the relationship between blood lipid parameters and whole blood iron levels has remained unclear. Based on a community population, the study aimed to explore the relationship between whole blood iron levels and blood lipids in Taizhou, China. The blood samples were collected from 1917 community residents, and levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and whole blood iron were measured. Pearson correlation was used to analyze the correlation between whole blood iron levels and lipids profile parameters. The results of the study showed that for both men and women, whole blood iron concentration was positively correlated with total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P < 0.001), but not with high-density lipoprotein cholesterol (P = 0.618, P = 0.083). The positive correlation between whole blood iron and triglycerides was the most significant (P < 0.001, r = 0.138). The above trends were more pronounced among men than among women. Therefore, the study suggested that regulating whole blood iron levels of populations in Taizhou, China, may be a potential strategy for regulating triglycerides, total cholesterol, and low-density lipoprotein. The potential for controlling triglycerides by regulating whole blood iron is more apparent. The result of the study has some implications for the prevention and diagnosis of dyslipidemia among medical staff and residents, especially male residents.
Competing Interests: Declarations. Ethics Approval: The study involved collecting blood from community residents. The questionnaire and methodology for this study were approved by the Human Research Ethics Committee of Taizhou University (No. 2024006). Consent to Participate: Informed consent was obtained from all individual participants included in the study. Consent for Publication: The authors affirm that human research participants provided informed consent for the publication of the data in Tables 1, 2, 3, and Figs. 1, 2a, b, c, and d. Competing Interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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