Advancements in organic fluorescent materials: unveiling the potential of peripheral group modification in dithienyl-diketopyrrolopyrrole derivatives for one- and two-photon bioimaging.

Autor:	Zucolotto Cocca LH; Photonics Group, Institute of Physics, Federal University of Goiás, Goiânia, 74690-900, GO, Brazil. leandro.zucolottococca@gmail.com.; Sao Carlos Physics Institute, University of São Paulo, CP 369, 13560-970 São Carlos, SP, Brazil., Valverde JVP; Sao Carlos Physics Institute, University of São Paulo, CP 369, 13560-970 São Carlos, SP, Brazil., Leite CM; Nanomedicine and Nanotoxicology Group, Sao Carlos Physics Institute, University of São Paulo, 13560-970 São Carlos, SP, Brazil., Moreno NS; Nanomedicine and Nanotoxicology Group, Sao Carlos Physics Institute, University of São Paulo, 13560-970 São Carlos, SP, Brazil., Neto AL; Graduate Program in Chemistry, Federal University of Technology - Parana (UTFPR), CP 81531-990 Curitiba, Brazil., Macedo AG; Graduate Program in Chemistry, Federal University of Technology - Parana (UTFPR), CP 81531-990 Curitiba, Brazil.; Graduate Program in Physics and Astronomy, Federal University of Technology - Paraná (UTFPR), CP 81531-990 Curitiba, Brazil., Pratavieira S; Sao Carlos Physics Institute, University of São Paulo, CP 369, 13560-970 São Carlos, SP, Brazil., Silva DL; Department of Natural Sciences, Mathematics and Education, Federal University of São Carlos, Rod. Anhanguera - Km 174, 13600-970 Araras, SP, Brazil., Rodrigues PC; Graduate Program in Chemistry, Federal University of Technology - Parana (UTFPR), CP 81531-990 Curitiba, Brazil.; Graduate Program in Physics and Astronomy, Federal University of Technology - Paraná (UTFPR), CP 81531-990 Curitiba, Brazil., Zucolotto V; Nanomedicine and Nanotoxicology Group, Sao Carlos Physics Institute, University of São Paulo, 13560-970 São Carlos, SP, Brazil., Mendonça CR; Sao Carlos Physics Institute, University of São Paulo, CP 369, 13560-970 São Carlos, SP, Brazil., De Boni L; Sao Carlos Physics Institute, University of São Paulo, CP 369, 13560-970 São Carlos, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of materials chemistry. B [J Mater Chem B] 2024 Dec 04. Date of Electronic Publication: 2024 Dec 04.
DOI:	10.1039/d4tb02291b
Abstrakt:	The quest for novel organic fluorescent materials capable of two-photon absorption (2PA) has intensified in recent years due to their promising applications in biological imaging. Two-photon fluorescence microscopy (2PFM) offers high spatial-temporal resolution, reduced photodamage, and deeper tissue penetration compared to conventional techniques. However, the development of bright two-photon molecular markers remains a challenge, necessitating compounds with high fluorescence quantum yield and 2PA cross-section ( σ 2PA ). Strategies such as increasing π-conjugation have shown promise but are hindered by synthesis complexities and limited biocompatibility. Alternatively, incorporating electron-donating (ED) or electron-withdrawing (EW) peripheral groups in a main structure has emerged as a viable approach, leading to significant enhancements in σ 2PA . This study highlights the advantages and challenges of these strategies, emphasizing the importance of exploring new organic compounds and evaluating the efficacy of peripheral groups for advanced two-photon bioimaging applications.
Databáze:	MEDLINE
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