Integrating Heat-Stable Carbetocin and Tranexamic Acid for Prevention and Management of Postpartum Hemorrhage in Sub-Saharan Africa: A Five-Country Pilot Implementation Study.

Autor:	Rushwan S; Concept Foundation, Avenue de Sécheron, Geneva, Switzerland., Forna F; Mama-Pikin Foundation, Wallace Johnson Street, Freetown, Sierra Leone., Abubeker FA; St. Paul's Hospital Millenium Medical College, Swaziland Street, Addis Ababa, Ethiopia., Tufa T; St. Paul's Hospital Millenium Medical College, Swaziland Street, Addis Ababa, Ethiopia., Millogo T; Institut Africain de Santé Publique, Ouagadougou, Burkina Faso., Nakalembe M; Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda., Adu-Bonsaffoh K; Department of Obstetrics and Gynecology, University of Ghana Medical School, P.O. Box GP 4236, Accra, Ghana., Moses FL; Ministry of Health, Sierra Leone, College of Medicine & Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Chinery L; Concept Foundation, Avenue de Sécheron, Geneva, Switzerland., Piaggio G; Concept Foundation, Avenue de Sécheron, Geneva, Switzerland., Gülmezoglu M; Concept Foundation, Avenue de Sécheron, Geneva, Switzerland.
Jazyk:	angličtina
Zdroj:	International journal of MCH and AIDS [Int J MCH AIDS] 2024 Sep 23; Vol. 13 (Suppl 1), pp. S15-S27. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI:	10.25259/IJMA_34_2024
Abstrakt:	Background and Objective: Globally, postpartum hemorrhage (PPH) remains the most common direct cause of maternal mortality. This study evaluated the feasibility and acceptability of introducing heat-stable carbetocin (HSC) for PPH prevention and tranexamic acid (TXA) for PPH treatment in five Sub-Saharan African countries following recent World Health Organization (WHO) recommendations. This study also assessed healthcare providers' (HCPs') favorability toward using these medicines. Methods: We conducted a mixed methods pilot implementation study in selected facilities across Burkina Faso, Ethiopia, Ghana, Sierra Leone, and Uganda between May and December 2022. We compared baseline data obtained from patient registers with data collected during implementation on the safe and appropriate use of HSC and TXA using descriptive statistics. HCP responses were analyzed qualitatively using a thematic analysis. Results: Following training, HSC was administered prophylactically in 11,329 (92.4%) of 12,262 deliveries in all study facilities which received a uteorotonic for PPH prevention during implementation and was used safely and appropriately. TXA administration for PPH treatment was done safely, appropriately, and within the WHO-recommended time. No adverse events were reported throughout the study. HCPs overall showed high confidence in, and favorability toward, using both medicines. Conclusion and Global Health Implications: Our study demonstrated that HSC and TXA can be safely and appropriately implemented in primary and tertiary facilities, and their introduction is feasible and acceptable from the perspective of HCPs. A holistic approach to training and regular supportive supervision is needed to ensure the continued safe use of these new and lesser-utilized PPH medicines. Dedicated training is required to improve the documentation of patient charts on PPH care. Introducing these medicines holds promise for improving PPH care in low- and middle-income countries, including by addressing suboptimal efficacy due to cold chain system challenges. Competing Interests: The authors declare no competing interests. (© 2024 The Authors. Published by Global Health and Education Projects, Inc., USA.)
Databáze:	MEDLINE
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