Predisposing factors for poor outcomes after intense pulsed light treatment for dry eye disease: A retrospective case-control study.

Autor:	Lee CY; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Nobel Eye Institute, Taipei, Taiwan.; Department of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung, Taiwan., Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan., Chen HC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan.; Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan., Chang CK; Nobel Eye Institute, Taipei, Taiwan.; Department of Optometry, Da-Yeh University, Chunghua, Taiwan.
Jazyk:	angličtina
Zdroj:	International journal of medical sciences [Int J Med Sci] 2024 Nov 04; Vol. 21 (15), pp. 2919-2925. Date of Electronic Publication: 2024 Nov 04 (Print Publication: 2024).
DOI:	10.7150/ijms.101341
Abstrakt:	Purpose: To evaluate the potential risk factors for poor dry eye disease (DED) outcomes after intense pulse light (IPL) treatment. Methods: A retrospective case-control study was conducted, and patients who received IPL were enrolled. A total of 63 eyes were included in the present study after exclusion and were divided into a fair outcome group and a poor outcome group according to posttreatment improvements in DED-related signs and symptoms. The primary outcomes are the pretreatment parameters between the two groups. The Mann‒Whitney U test and generalized linear model were adopted to analyze the differences in pretreatment indices between the two groups. Results: Both the fluorescein stain results and the Schirmer II test results after IPL treatment were significantly better than those before IPL treatment (both P < 0.05). Nevertheless, the overall DED-related symptoms did not significantly improve after IPL treatment (P = 0.834). In terms of indicators of poor outcomes after IPL treatment, the rates of advanced age, female sex, previous refractive surgery, lower pretreatment noninvasive tear break-up time (NITBUT) and greater meibomian gland loss were significantly greater in the poor outcome group (all P < 0.05). Female sex and previous refractive surgery were associated with less improvement in DED-related symptoms (all P < 0.05), whereas advanced age, a lower pretreatment NITBUT and a higher meibomian gland loss rate were related to poor DED sign improvement (all P < 0.05). Conclusion: The major limitations are the retrospective design, small study population, and absence of detailed posttreatment exams. In conclusion , old age, female sex, previous refractive surgery, a lower NITBUT, and a higher meibomian gland loss rate are associated with worse outcomes after IPL treatment. Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).)
Databáze:	MEDLINE
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