Age-related changes in pupil dynamics and task modulation across the healthy lifespan.

Autor:	Huang J; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Smorenburg ML; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Yep R; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Riek HC; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Calancie OG; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Kirkpatrick RH; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.; School of Medicine, Queen's University, Kingston, ON, Canada., Brien DC; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Coe BC; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Wang CA; Eye-Tracking Laboratory, Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan., Munoz DP; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Nov 19; Vol. 18, pp. 1445727. Date of Electronic Publication: 2024 Nov 19 (Print Publication: 2024).
DOI:	10.3389/fnins.2024.1445727
Abstrakt:	The pupil is modulated by luminance, arousal, bottom-up sensory, and top-down cognitive signals, and has increasingly been used to assess these aspects of brain functioning in health and disease. However, changes in pupil dynamics across the lifespan have not been extensively examined, hindering our ability to fully utilize the pupil in probing these underlying neural processes in development and aging in healthy and clinical cohorts. Here, we examined pupil responses during the interleaved pro-/anti-saccade task (IPAST) in healthy participants across the lifespan ( n  = 567, 5-93 years of age). Based on the extracted measurements of pupil dynamics, we demonstrated age-related changes in pupil measures and task modulation. Moreover, we characterized the underlying factors and age-related effects in components of pupil responses that may be attributed to developmental and aging changes in the associated brain regions. Finally, correlations between factors of pupil dynamics and saccade behaviors revealed evidence of shared neural processes in the pupil and saccade control circuitries. Together, these results demonstrate changes in pupil dynamics as a result of development and aging, providing a baseline with which altered pupil responses due to neurological deficits at different ages can be studied. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Huang, Smorenburg, Yep, Riek, Calancie, Kirkpatrick, Brien, Coe, Wang and Munoz.)
Databáze:	MEDLINE
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