Risk Factors for Perforation in Endoscopic Treatment for Early Colorectal Cancer: A Nationwide ENTER-K Study.

Autor:	Jo IH; Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea., Kim HG; Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea., Cho YS; Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea., Lee HJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Kim ER; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Lee YJ; Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea., Hwang SW; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Kim KO; Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea., Lee J; Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea., Choi HS; Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea., Jung Y; Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea., Moon CM; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
Jazyk:	angličtina
Zdroj:	Gut and liver [Gut Liver] 2024 Dec 04. Date of Electronic Publication: 2024 Dec 04.
DOI:	10.5009/gnl240210
Abstrakt:	Background/aims: Early colorectal cancer (ECC) is commonly resected endoscopically. Perforation is a devastating complication of endoscopic resection. We aimed to identify the characteristics and predictive risk factors for perforation related to endoscopic resection of ECC. Methods: This nationwide retrospective multicenter study included patients with ECC who underwent endoscopic resection. We investigated the demographics, endoscopic findings at the time of treatment, and histopathological characteristics of the resected specimens. Logistic regression analysis was used to investigate the clinical factors associated with procedure-related perforations. Survival analysis was conducted to assess the impact of perforation on the overall survival of patients with ECC. Results: This study included 965 participants with a mean age of 63.4 years. The most common endoscopic treatment was conventional endoscopic mucosal resection (n=573, 59.4%), followed by conventional endoscopic submucosal dissection (n=259, 26.8%). Thirty-three patients (3.4%) experienced perforations, most of which were managed endoscopically (n=23/33, 69.7%). Patients who undergo endoscopic submucosal dissection-hybrid and precut endoscopic mucosal resection have a higher risk of perforation than those who undergo conventional endoscopic mucosal resection (odds ratio, 78.65 and 39.72, p<0.05). Procedure-related perforations were not associated with patient survival. Conclusions: Perforation after endoscopic resection had no significant impact on the prognosis of ECC. The type of endoscopic resection was a crucial predictor of perforation. Large-scale prospective studies are needed to further investigate endoscopic resection of ECC.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu