Sporothrix brasiliensis as the major causative species of the zoonotic outbreak of human sporotrichosis in the Brazilian Amazon.

Autor:	de Souza GC; Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil., de Brito EM; Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil., de Lima Fernandes DC; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., Frota MZM; Universidade Federal do Amazonas, Manaus, Amazonas, Brazil., de Araújo Santos FJ; Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., de Oliveira Ferreira C; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., Dos Santos Silva CG; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., Nakajima SR; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., Pennini SN; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., Talhari S; Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., Pedrosa VL; Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil., Mira M; Graduate Program in Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil., Miot HA; Departamento de Dermatologia da FMB-UNESP, Botucatu, São Paulo, Brazil., Talhari C; Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.; Departamento de Dermatologia da Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil., Leturiondo AL; Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.; Fundação Hospitalar Alfredo da Matta de Dermatologia, Manaus, Amazonas, Brazil.
Jazyk:	angličtina
Zdroj:	Tropical medicine & international health : TM & IH [Trop Med Int Health] 2024 Dec 03. Date of Electronic Publication: 2024 Dec 03.
DOI:	10.1111/tmi.14065
Abstrakt:	Background: Sporotrichosis is a neglected tropical disease and the most common subcutaneous mycosis, mainly caused by Sporothrix species, particularly S. brasiliensis, S. schenckii and S. globosa, which exhibit varying biological behaviours and virulence. The epidemic of sporotrichosis in Brazil, initiated in Rio de Janeiro in the late 1990s, rapidly spread to other states, including Amazonas in 2021. This study aimed to identify the specific Sporothrix species responsible for the human sporotrichosis outbreak in the Brazilian Amazon. Methods: A cross-sectional study was conducted by enrolling clinically suspected cases of sporotrichosis attended at a reference dermatologic centre, in Manaus (Brazil). Biological material was collected from their skin lesions for culture (Mycosel) and for species identification (qPCR). Results: Sporothrix cultures were obtained from 150 cases. Sporotrichosis predominantly affected females (67.3%), aged 44.5 years on average, with lymphocutaneous lesions (72.7%). Sporothrix brasiliensis was identified in 89.3% of patients. Up to 83.3% of these patients reported contact with cats previously to the skin lesion, and the time-spatial progression of the human cases followed the notification of cases in cats, in the metropolitan region of Manaus. Conclusion: Sporothrix brasiliensis is the dominant species in the zoonotic outbreak of human sporotrichosis in the Brazilian Amazon, with cats identified as the primary vectors. Effective sanitary control measures, education and responsible pet ownership are crucial to mitigating zoonotic sporotrichosis' impact in Brazil and preventing its spread to neighbouring Latin American cities. (© 2024 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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